| Familial Hurthle cell carcinoma of the thyroid: case reports and review of the literature. | |
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MedLine Citation:
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PMID: 19585901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe case reports of a brother and sister pair with Hurthle cell carcinoma of thyroid. METHODS: The clinical presentation, diagnostic workup, treatment and clinical course of HCC is described for both patients. Relevant family history is discussed. This is followed by a review of literature regarding genetic basis of familial and sporadic HCC. RESULTS: Both cases have striking similarities in their presentation and disease progression. Both had the disease diagnosed in later years of life, had cold nodules for 4-5 years before histological diagnosis, and both had local recurrence following thyroidectomy and postoperative radioiodine ablation. Local recurrence was treated with external radiation in each patient and both of them had persistent elevation of serum thyroglobulin levels with negative diagnostic whole body I-131 scans. Later on pulmonary metastatic disease was documented in each patient. Family history was pertinent for benign nodular thyroid disease in multiple family members. CONCLUSION: HCC is a rare malignancy of thyroid. Genetic basis of familial HCC remains to be elucidated. Our case describes a rare familial occurrence of this malignancy and highlights the importance of obtaining a careful family history in management and surveillance of thyroid cancer. |
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Authors:
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Abid Yaqub |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: The West Virginia medical journal Volume: 105 ISSN: 0043-3284 ISO Abbreviation: W V Med J Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-07-09 Completed Date: 2009-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413777 Medline TA: W V Med J Country: United States |
Other Details:
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Languages: eng Pagination: 23-8 Citation Subset: IM |
Affiliation:
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Section of Endocrinology and Metabolism, Joan C Edwards School of Medicine, Marshall University, Huntington, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma, Oxyphilic
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genetics*,
pathology,
surgery Aged Fatal Outcome Female Humans Lung Diseases / radiography Multiple Pulmonary Nodules / radiography Pedigree Thyroid Neoplasms / genetics*, pathology, surgery Thyroidectomy Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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