Document Detail


Familial Hurthle cell carcinoma of the thyroid: case reports and review of the literature.
MedLine Citation:
PMID:  19585901     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe case reports of a brother and sister pair with Hurthle cell carcinoma of thyroid. METHODS: The clinical presentation, diagnostic workup, treatment and clinical course of HCC is described for both patients. Relevant family history is discussed. This is followed by a review of literature regarding genetic basis of familial and sporadic HCC. RESULTS: Both cases have striking similarities in their presentation and disease progression. Both had the disease diagnosed in later years of life, had cold nodules for 4-5 years before histological diagnosis, and both had local recurrence following thyroidectomy and postoperative radioiodine ablation. Local recurrence was treated with external radiation in each patient and both of them had persistent elevation of serum thyroglobulin levels with negative diagnostic whole body I-131 scans. Later on pulmonary metastatic disease was documented in each patient. Family history was pertinent for benign nodular thyroid disease in multiple family members. CONCLUSION: HCC is a rare malignancy of thyroid. Genetic basis of familial HCC remains to be elucidated. Our case describes a rare familial occurrence of this malignancy and highlights the importance of obtaining a careful family history in management and surveillance of thyroid cancer.
Authors:
Abid Yaqub
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The West Virginia medical journal     Volume:  105     ISSN:  0043-3284     ISO Abbreviation:  W V Med J     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-07-09     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413777     Medline TA:  W V Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-8     Citation Subset:  IM    
Affiliation:
Section of Endocrinology and Metabolism, Joan C Edwards School of Medicine, Marshall University, Huntington, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenoma, Oxyphilic / genetics*,  pathology,  surgery
Aged
Fatal Outcome
Female
Humans
Lung Diseases / radiography
Multiple Pulmonary Nodules / radiography
Pedigree
Thyroid Neoplasms / genetics*,  pathology,  surgery
Thyroidectomy
Tomography, X-Ray Computed

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