Document Detail


Familial Down's syndrome.
MedLine Citation:
PMID:  145469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A family is reported in which the same mother conceived two children with trisomy 21. The pregnancy with the second affected child was interrupted after diagnostic amniocentesis. Maternal chromosome analysis was normal. This family and those previously reported suggest that there is an increased recurrence risk of trisomy 21 after the birth of an affected individual, possibly caused by a genetic tendency for non-disjunction. After the birth of a child with Down's syndrome, amniocentesis and chromosome analysis of cultured amniotic fluid cells is indicated in each further pregnancy, irrespective of maternal age.
Authors:
J Chemke; B Goldman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal de génétique humaine     Volume:  25     ISSN:  0021-7743     ISO Abbreviation:  J Genet Hum     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2983308R     Medline TA:  J Genet Hum     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Down Syndrome / genetics*
Female
Humans
Maternal Age
Meiosis
Parity
Pedigree
Pregnancy
Risk

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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