Document Detail


Familial Bell's palsy in females: a phenotype with a predilection for eyelids and lacrimal gland.
MedLine Citation:
PMID:  16191801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors report a family with familial Bell's palsy affecting seven individuals, six of whom are females. This is a distinct subtype of Bell's palsy with a predilection for juvenile females, previously reported only very rarely. In conjunction with a review of the literature, this case suggests that this phenotype carries with it a greater risk of serious complications affecting the eyelids and lacrimal gland. These carry significant functional and cosmetic implications owing to aberrant regeneration of the seventh, sixth and possibly third cranial nerves, chronicity and relapses. Clinical features include synkinesis of the eyelids with the orbicularis oris causing synkinetic ptosis, recurrent paralytic ectropion, paralysis of facial muscles of expression with dry eye, hyperlacrimation (crocodile tears), and transient strabismus. Clinically, the decision to offer surgery in place of conservative treatment should consider the natural history of chronicity and relapses often seen with this subtype of familial Bell's palsy. Botulinum toxin injections are especially versatile in managing the complications associated with this phenotype.
Authors:
Farhan H Zaidi; Kevin Gregory-Evans; James F Acheson; Veronica Ferguson
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Orbit (Amsterdam, Netherlands)     Volume:  24     ISSN:  0167-6830     ISO Abbreviation:  Orbit     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-09-29     Completed Date:  2005-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301221     Medline TA:  Orbit     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  121-4     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology and Visual Neuroscience, Imperial College London, and The Western Eye Hospital, London, U.K. f.zaidi@imperial.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Bell Palsy / complications,  genetics*
Consanguinity
Eye Diseases / etiology,  genetics*
Eyelids
Female
Genetic Predisposition to Disease
Humans
Lacrimal Apparatus
Phenotype
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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