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False positives on both dexamethasone testing and urinary free cortisol in women on oral contraception: dose-response effects.
MedLine Citation:
PMID:  23140463     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The biochemical diagnosis of hypercortisolism is challenging during treatment with oral contraceptives (OC). In previous studies, it has been shown that serum cortisol levels are often elevated on OC and that the dexamethasone suppression test (DST) may give false positive results(1,2) . However, most studies were performed in the 1980s, a time when other cut-off values for cortisol concentrations were applied. Domisse et al. found almost all of the patients studied to show adequate suppression of cortisol on OC (containing 0.05 and 0.08 mg mestranol) employing 13.8 nmol/L (5 μg/dL) as the cut-off for adequate suppression(3) , while Nickelsen et al. reported false-positive rates for the overnight DST in 50% of women taking the oral contraceptive pill (0.03-0.05 mg ethinylestradiol (EE2))(2) . © 2012 Blackwell Publishing Ltd.
Authors:
Myrella Paschali; Holger S Willenberg; Reimar Fritzen; Matthias Schott; Werner A Scherbaum; Sven Schinner
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Publication Detail:
Type:  LETTER     Date:  2012-11-12
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Department of Endocrinology, Diabetes and Rheumatology, University Dusseldorf, Medical Faculty, D-40225, Dusseldorf, Germany.
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