Document Detail

False-positive serum and bronchoalveolar lavage Aspergillus galactomannan assays caused by different antibiotics.
MedLine Citation:
PMID:  20192889     Owner:  NLM     Status:  MEDLINE    
Our objective was to identify false-positive serum and bronchoalveolar lavage (BAL) fluid galactomannan (GM) tests caused by various antibiotics commonly used in general practice. Serum and BAL samples from patients who did not have the diagnostic criteria of invasive aspergillosis and received different antibiotics were prospectively analyzed for GM. Serum and BAL samples were also collected from patients who did not receive antibiotics. At the cut-off index of >or=0.5, false-positive serum results were found in patients who received amoxicillin-clavulanate, piperacillin-tazobactam, cefepime, and cefoperazone-sulbactam (26.7%, 58.3%, 14.3%, and 66.7%, respectively). Fungal colonization in BAL samples had a higher BAL GM than those without fungal colonization. In 71 patients who had a negative BAL culture for fungi, at the cut-off value of >or=1.0, false-positive BAL fluid results were found in patients who received amoxicillin-clavulanate (27.3%), piperacillin-tazobactam (50%), cefepime (16.7%), carbapenem (45.5%), and ceftriaxone (45.5%). False-positive serum and BAL GM assays were also detected in patients who did not receive any antibiotics. In summary, this study demonstrates the false-positive GM levels in serum and BAL caused by beta-lactam antibiotics that are commonly used in general practice. Physicians should be aware of this possible interference.
Viboon Boonsarngsuk; Anuchit Niyompattama; Chalermporn Teosirimongkol; Kanchana Sriwanichrak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  42     ISSN:  1651-1980     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-07     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  461-8     Citation Subset:  IM    
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis / statistics & numerical data*
Antigens, Fungal* / analysis,  blood
Aspergillosis / diagnosis*
Bronchoalveolar Lavage Fluid / chemistry*
Chi-Square Distribution
False Positive Reactions
Mannans* / analysis,  blood
Middle Aged
Predictive Value of Tests
Prospective Studies
Statistics, Nonparametric
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antigens, Fungal; 0/Mannans; 11078-30-1/galactomannan

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