Document Detail

False-positive quadruple screen test for trisomy 18 in a patient with a fetus with Bloom's syndrome.
MedLine Citation:
PMID:  17361088     Owner:  NLM     Status:  MEDLINE    
In the literature, conflicting reports on the significance of false-positive maternal serum multiple marker testing for trisomy 18 are encountered; however, the biology of this finding is discussed infrequently. We present such a case in association with Bloom's syndrome in the fetus. The fetus had intrauterine growth restriction, seen early in the second trimester, oligohydramnios, and was delivered at 34 weeks of gestation for impending fetal compromise. We propose that the adverse outcome of the pregnancy with false-positive serum analyte testing for trisomy 18 might result from a small-sized placenta and perhaps pathology at receptor level.
Laxmi Baxi; Stephen Brown; Harshwardhan M Thaker
Related Documents :
17361088 - False-positive quadruple screen test for trisomy 18 in a patient with a fetus with bloo...
12504768 - Valproic acid and lamotrigine treatment during pregnancy. the risk of chromosomal abnor...
17267838 - Absent or shortened nasal bone length and the detection of down syndrome in second-trim...
3905068 - Any place for antenatal diagnosis in the third trimester of pregnancy?
11179058 - Comparison of spontaneous vs. metronome-guided breathing on assessment of vagal modulat...
23850528 - The combined association of psychosocial stress and chronic hypertension with preeclamp...
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2007-03-15
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  22     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-15     Completed Date:  2007-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  318-20     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University, Sloane Hospital for Women at Columbia University Medical Center of NY Presbyterian Hospital, New York, NY, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood*
Bloom Syndrome / blood,  diagnosis*,  embryology,  genetics,  pathology
Cesarean Section, Repeat
Chorionic Gonadotropin, beta Subunit, Human / blood
Chromosomes, Human, Pair 18*
Estriol / blood
False Positive Reactions
Fetal Growth Retardation / diagnosis
Inhibins / blood
Live Birth
Oligohydramnios / diagnosis
Placenta / pathology*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prenatal Diagnosis*
Trisomy / diagnosis*,  genetics,  pathology
Ultrasonography, Prenatal
alpha-Fetoproteins / metabolism
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/alpha-Fetoproteins; 50-27-1/Estriol; 57285-09-3/Inhibins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oxidative stress alters the integrity of cell-free mRNA fragments associated with placenta-derived s...
Next Document:  Production of inflammatory molecules in peripheral blood mononuclear cells from severely glucose-6-p...