| False-positive amniotic fluid acetylcholinesterase analysis in the third trimester. | |
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MedLine Citation:
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PMID: 8341634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty-two third-trimester amniotic fluid samples were studied according to the indication for amniocentesis, result of acetylcholinesterase (AChE) analysis, and outcome, in order to address the issue of the effectiveness of AChE testing late in gestation. The results indicate that third-trimester AChE analysis is less effective than second trimester in distinguishing open neural tube defects (ONTDs) and ventral wall defects (VWDs) from other abnormalities. False-positive results occurred in cases of isolated hydrocephaly (four of seven cases), polyhydramnios, and intrauterine growth retardation (IUGR). Caution is recommended in interpreting third-trimester AChE tests, particularly when neither an ONTD nor a VWD is observed by ultrasound. |
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Authors:
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S F Suchy; M T Yeager |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 13 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-08-31 Completed Date: 1993-08-31 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 363-9 Citation Subset: IM |
Affiliation:
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Greenwood Genetic Center, SC 29646. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Muscles
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abnormalities Acetylcholinesterase / analysis* Amniotic Fluid / chemistry* Diagnosis, Differential Evaluation Studies as Topic False Positive Reactions Female Fetal Growth Retardation / diagnosis Humans Hydrocephalus / diagnosis, ultrasonography Neural Tube Defects / diagnosis*, ultrasonography Polyhydramnios / diagnosis, ultrasonography Pregnancy Pregnancy Trimester, Third Prenatal Diagnosis |
| Chemical | |
Reg. No./Substance:
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EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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