| False-positive IgM for CMV in pregnant women with autoimmune disease: a novel prognostic factor for poor pregnancy outcome. | |
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MedLine Citation:
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PMID: 20305050 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our aims were to assess the frequency of false-positive IgM antibodies for cytomegalovirus in pregnant women with autoimmune diseases and in healthy women (controls) and to determine their relationship with pregnancy outcome. Data from 133 pregnancies in 118 patients with autoimmune diseases and from 222 pregnancies in 198 controls were assessed. When positive IgM for cytomegalovirus was detected, IgG avidity, cytomegalovirus isolation and polymerase chain reaction for CMV-DNA in maternal urine and amniotic fluid samples were performed in order to identify primary infection or false positivity. A statistically significantly higher rate of false-positive IgM was found in pregnancies with autoimmune diseases (16.5%) in comparison with controls (0.9%). A worse pregnancy outcome was observed among patients with autoimmune disease and false cytomegalovirus IgM in comparison with those without false positivity: earlier week of delivery (p = 0.017), lower neonatal birth weight (p = 0.0004) and neonatal birth weight percentile (p = 0.002), higher rate of intrauterine growth restriction (p = 0.02) and babies weighing less than 2000 g (p = 0.025) were encountered. The presence of false cytomegalovirus IgM in patients with autoimmune diseases could be used as a novel prognostic index of poor pregnancy outcome: it may reflect a non-specific activation of the immune system that could negatively affect pregnancy outcome. Lupus (2010) 19, 844-849. |
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Authors:
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S De Carolis; S Santucci; A Botta; S Garofalo; C Martino; A Perrelli; S Salvi; Va Degennaro; Ag de Belvis; S Ferrazzani; G Scambia |
Publication Detail:
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Type: Journal Article Date: 2010-03-19 |
Journal Detail:
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Title: Lupus Volume: 19 ISSN: 1477-0962 ISO Abbreviation: Lupus Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-09 Revised Date: 2011-03-11 |
Medline Journal Info:
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Nlm Unique ID: 9204265 Medline TA: Lupus Country: England |
Other Details:
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Languages: eng Pagination: 844-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmune Diseases
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complications* Birth Weight Case-Control Studies Cytomegalovirus Infections / complications, diagnosis* Delivery, Obstetric False Positive Reactions Female Humans Immunoglobulin M / blood* Infant, Newborn Polymerase Chain Reaction Pregnancy Pregnancy Complications, Infectious / diagnosis* Pregnancy Outcome Prognosis Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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