| False-negative stool occult blood tests caused by ingestion of ascorbic acid (vitamin C). | |
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MedLine Citation:
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PMID: 1200528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a female patient with unexplained anemia, ascorbic acid ingestion and apparent false-negative occult blood tests were related. When she stopped ascorbic acid, her stools became strongly reactive ("4+") by three tests for occult stool blood; this association was observed repeatedly. A test developed to measure stool occult blood in the presence of ascorbic acid remained reactive throughout this observation, and the observation was confirmed by in-vitro studies. Current tests for occult blood depend on the pseudoperoxidase activity of heme and are inhibited by low levels of ascorbic acid. Reducing substances chemically similar to ascorbic acid also inhibits occult blood tests; oxidized ascorbic acid and sulfhydryl reducing agents do not inhibit them at physiologic levels. |
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Authors:
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R M Jaffe; B Kasten; D S Young; J D MacLowry |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of internal medicine Volume: 83 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1975 Dec |
Date Detail:
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Created Date: 1976-02-13 Completed Date: 1976-02-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 824-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ascorbic Acid
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pharmacology* False Negative Reactions Female Humans Occult Blood* |
| Chemical | |
Reg. No./Substance:
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50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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