Document Detail

False-negative rates of tumor metastases in the histologic examination of bone marrow.
MedLine Citation:
PMID:  9950159     Owner:  NLM     Status:  MEDLINE    
Recent reports have claimed that bone marrow histology is less sensitive for detecting metastatic tumor than are other methods of marrow examination. These reports, however, did not specify methodologic information, such as the number of slides or tissue sections reviewed. To demonstrate the importance of specifying such information, we reviewed archival, tumor-positive marrow biopsy specimens from our laboratory. By means of a statistical model, we calculated the false-negative rates that would have occurred had random histologic review entailed fewer than 10 slides. Our model demonstrates a progressive increase in the percentage of false-negative diagnoses with the review of fewer slides, e.g., from 1% with review of nine slides to as high as 24% with review of only two slides. We conclude that the number of histologic slides and tissue sections reviewed should be specified when comparing bone marrow histologic examination with other techniques of marrow assessment.
A Jatoi; G E Dallal; P L Nguyen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  12     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-14     Completed Date:  1999-04-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  29-32     Citation Subset:  IM    
Department of Medicine, New England Medical Center, Boston, Massachusetts, USA.
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MeSH Terms
Biopsy / methods,  standards
Bone Marrow / pathology*
False Negative Reactions
Neoplasm Metastasis / pathology*
Retrospective Studies
Comment In:
Mod Pathol. 1999 Aug;12(8):840-1   [PMID:  10463489 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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