Document Detail


False-negative rates of tumor metastases in the histologic examination of bone marrow.
MedLine Citation:
PMID:  9950159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent reports have claimed that bone marrow histology is less sensitive for detecting metastatic tumor than are other methods of marrow examination. These reports, however, did not specify methodologic information, such as the number of slides or tissue sections reviewed. To demonstrate the importance of specifying such information, we reviewed archival, tumor-positive marrow biopsy specimens from our laboratory. By means of a statistical model, we calculated the false-negative rates that would have occurred had random histologic review entailed fewer than 10 slides. Our model demonstrates a progressive increase in the percentage of false-negative diagnoses with the review of fewer slides, e.g., from 1% with review of nine slides to as high as 24% with review of only two slides. We conclude that the number of histologic slides and tissue sections reviewed should be specified when comparing bone marrow histologic examination with other techniques of marrow assessment.
Authors:
A Jatoi; G E Dallal; P L Nguyen
Related Documents :
7658939 - Effect of foot posture on the incidence of medial tibial stress syndrome.
17434589 - The quality of reporting of diagnostic accuracy studies of optical coherence tomography...
9557269 - Papnet computer-aided rescreening for detection of benign and malignant glandular eleme...
24440319 - Primary and secondary intralymphatic histiocytosis.
15214829 - Cytologic features of high-grade squamous intraepithelial lesion in thinprep papanicola...
24703259 - Eyelid milia en plaque: a treatment challenge with a new co2 fractional laser.
22058679 - Retraction of articles.
19186109 - Obstructive complications of lichen sclerosus.
9218899 - Tall cell variant of papillary thyroid carcinoma: cytologic features and differential d...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  12     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-14     Completed Date:  1999-04-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  29-32     Citation Subset:  IM    
Affiliation:
Department of Medicine, New England Medical Center, Boston, Massachusetts, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biopsy / methods,  standards
Bone Marrow / pathology*
False Negative Reactions
Humans
Neoplasm Metastasis / pathology*
Retrospective Studies
Comments/Corrections
Comment In:
Mod Pathol. 1999 Aug;12(8):840-1   [PMID:  10463489 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Retroperitoneal leiomyosarcomas unassociated with the gastrointestinal tract: a clinicopathologic an...
Next Document:  Interstitial foam cells and oxidized lipoprotein in human glomerular disease.