Document Detail

False-negative food challenges in children with suspected food allergy.
MedLine Citation:
PMID:  11741628     Owner:  NLM     Status:  MEDLINE    
Food allergy can be diagnosed from an immediate-onset reaction after oral food challenge. We administered 370 challenges in 242 children; five (3%) of the 193 children tolerating foods on challenges developed immediate symptoms when the same preparation of foods was ingested openly at home the next day. We confirmed the food allergy by subsequent double-blind challenges. All children had positive skin-prick test reactions and all, but one, specific IgE antibodies to the offending foods. Our findings suggest that open feedings under observation, the day after negative challenges, are useful to eliminate false-negative challenge results.
C Caffarelli; T Petroccione
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Lancet     Volume:  358     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-19     Completed Date:  2002-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  1871-2     Citation Subset:  AIM; IM    
Paediatric Department, University of Parma, 43100, Parma, Italy.
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MeSH Terms
Child, Preschool
Double-Blind Method
Eggs / adverse effects*
False Negative Reactions
Food Hypersensitivity / diagnosis*
Milk / adverse effects*
Urticaria / etiology*
Comment In:
Lancet. 2002 Mar 16;359(9310):980-1   [PMID:  11918949 ]
Lancet. 2001 Dec 1;358(9296):1832-3   [PMID:  11741619 ]

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