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False-Negative Results of Endoscopic Biopsy in the Diagnosis of Gastrointestinal Kaposi's Sarcoma in HIV-Infected Patients.
MedLine Citation:
PMID:  23227427     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Kaposi's sarcoma (KS) is a rare endothelial neoplasm mainly involving the skin, but it is often associated with AIDS. Diagnosis of gastrointestinal (GI) tract KS, a common site of visceral involvement in AIDS, is important, but endoscopic biopsy carries a risk of false-negative results (FNRs) due to its submucosal appearance. This study sought to determine the rate and causes of FNR for endoscopic biopsy of GI-KS lesions. Endoscopic biopsy samples of 116 GI-KS lesions were reviewed retrospectively. All GI-KS lesions were confirmed to be resolved following KS therapy. FNRs were yielded for 41 of the lesions (35.3%). Among upper and lower GI sites, the esophagus was the only site significantly associated with FNRs (P < 0.01). Small size (<10 mm) and patches found on endoscopy were significantly associated with FNRs (P < 0.05). Findings of submucosal tumor (SMT) with ulceration were significantly associated with true-positive results (P < 0.05). In conclusion, FNRs were found in 35.3% of GI-KS lesions and were especially related to the site of the esophagus and endoscopic early stage (small size or patch appearance). An SMT with ulceration may be relatively easy to diagnose on endoscopic biopsy. Caution should be exercised when performing endoscopic biopsy of these lesions in AIDS patients and evaluating the histological features.
Authors:
Naoyoshi Nagata; Katsunori Sekine; Toru Igari; Yohei Hamada; Hirohisa Yazaki; Norio Ohmagari; Junichi Akiyama; Takuro Shimbo; Katsuji Teruya; Shinichi Oka; Naomi Uemura
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Publication Detail:
Type:  Journal Article     Date:  2012-11-26
Journal Detail:
Title:  Pathology research international     Volume:  2012     ISSN:  2042-003X     ISO Abbreviation:  Patholog Res Int     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-11     Completed Date:  2012-12-12     Revised Date:  2013-04-03    
Medline Journal Info:
Nlm Unique ID:  101526292     Medline TA:  Patholog Res Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  854146     Citation Subset:  -    
Affiliation:
Department of Gastroenterology, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
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