Document Detail

Fall in blood pressure in response to volume expansion in pregnancy-associated hypertension (pre-eclampsia): why does it occur?
MedLine Citation:
PMID:  6533186     Owner:  NLM     Status:  MEDLINE    
The infusion of 500 ml of a volume expanding solution caused a significant fall in blood pressure for up to 72 h in 35 women with pregnancy-associated hypertension of varying grades of severity. The response to the infusion was not obviously related to the clinical severity of the underlying disorder, nor to the extent of plasma volume expansion produced. The plasma volume of oedematous women increased, while there was no significant change in non-oedematous women in response to the infusion. Changes in other measurements were similar in oedematous and non-oedematous women. There was no evidence for prostacyclin release into the circulation in response to the infusion as a mediator of the blood pressure response. Both 6-keto-prostaglandin F1 alpha levels and 13,14-dihydro-15-keto-prostaglandin F (PGFM) levels fell significantly, suggesting suppression of prostaglandin release by the infusion. The antihypertensive effect of volume expanders in pregnancy-associated hypertension is mediated by a factor other than simple volume expansion.
E D Gallery; M D Mitchell; C W Redman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  2     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1985-06-03     Completed Date:  1985-06-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  177-82     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Blood Proteins / pharmacology
Hypertension / drug therapy,  physiopathology*
Isotonic Solutions / pharmacology
Magnesium Chloride
Plasma Substitutes / pharmacology*
Plasma Volume / drug effects
Potassium Chloride
Pre-Eclampsia / physiopathology*
Pregnancy Complications, Cardiovascular / physiopathology*
Proteinuria / physiopathology
Serum Albumin
Serum Globulins
Sodium Acetate
Sodium Chloride
Time Factors
Reg. No./Substance:
0/Blood Proteins; 0/Gluconates; 0/Isotonic Solutions; 0/Plasma Substitutes; 0/Plasma-lyte 148; 0/Serum Albumin; 0/Serum Globulins; 55963-80-9/plasma protein fraction; 6131-90-4/Sodium Acetate; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride; 7786-30-3/Magnesium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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