Document Detail

[Fall Risk and Fracture. Vitamin D and falls/fractures].
MedLine Citation:
PMID:  23628682     Owner:  NLM     Status:  In-Data-Review    
Vitamin D affects both bone and muscle. Recent meta-analyses of high-quality trials showed that both native vitamin D and active forms of vitamin D3 significantly reduced the risk of vertebral and non-vertebral fractures. These anti-fracture efficacies of vitamin D are considered to be mainly exerted through direct effects on mineral metabolism. In addition, recent evidence suggests that vitamin D significantly prevents falls, to indirectly reduce fall-related fractures. The preventive effect on falls by vitamin D is considered to be exerted through effects on muscle, at least in part. Eldecalcitol, a new active vitamin D3 analogue, increases bone mineral density and shows greater evident anti-fracture efficacy than alfacalcidol. However, its effects in preventing falls remain unclear and warrant clarification.
Naohisa Miyakoshi
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Clinical calcium     Volume:  23     ISSN:  0917-5857     ISO Abbreviation:  Clin Calcium     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433326     Medline TA:  Clin Calcium     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  695-700     Citation Subset:  IM    
Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Japan.
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