Document Detail

Fake or Fantasy: Rapid Dissociation between Strategic Content Monitoring and Reality Filtering in Human Memory.
MedLine Citation:
PMID:  21459836     Owner:  NLM     Status:  Publisher    
Memory verification is crucial for meaningful behavior. Orbitofrontal damage may impair verification and induce confabulation and inappropriate acts. The strategic retrieval account explains this state by deficient monitoring of memories' precise content, whereas the reality filter hypothesis explains it by a failure of an orbitofrontal mechanism suppressing the interference of memories that do not pertain to reality. The distinctiveness of these mechanisms has recently been questioned. Here, we juxtaposed these 2 mechanisms using high-resolution evoked potentials in healthy subjects who performed 2 runs of a continuous recognition task which contained pictures that precisely matched or only resembled previous pictures. We found behavioral and electrophysiological dissociation: Strategic content monitoring was maximally challenged by stimuli resembling previous ones, whereas reality filtering was maximally challenged by identical stimuli. Evoked potentials dissociated at 200-300 ms: Strategic monitoring induced a strong frontal negativity and a distinct cortical map configuration, which were particularly weakly expressed in reality filtering. Recognition of real repetitions was expressed at 300-400 ms, associated with ventromedial prefrontal activation. Thus, verification of a memory's concordance with the past (its content) dissociates from the verification of its concordance with the present. The role of these memory control mechanisms in the generation of confabulations and disorientation is discussed.
Aurélie Wahlen; Louis Nahum; Damien Gabriel; Armin Schnider
Related Documents :
12621346 - Dual-task study of cognitive and postural interference in patients with vestibular diso...
18978766 - Recent experiences of weight-based stigmatization in a weight loss surgery population: ...
7675616 - Dichoptic and physical information combination: a comparison.
16393036 - Interactions among the imagination, expertise reversal, and element interactivity effects.
23922306 - Clinical correlates in an experimental model of repetitive mild brain injury.
19966326 - Sociotopy in the temporoparietal cortex: common versus distinct processes.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-31
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  -     ISSN:  1460-2199     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratory of Cognitive Neurorehabilitation, Department of Clinical Neurosciences and Dermatology, Medical School, University of Geneva, CH-1211 Geneva 14, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dorsolateral prefrontal cortex modulates striatal reward encoding during reappraisal of reward antic...
Next Document:  Natural Scene Evoked Population Dynamics across Cat Primary Visual Cortex Captured with Voltage-Sens...