Document Detail


Failure of transdermal nitroglycerin to improve chronic stable angina: a randomized, placebo-controlled, double-blind, double crossover trial.
MedLine Citation:
PMID:  6439019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the effect of transdermal nitroglycerin (NTG-TTS), releasing 5 mg/24 hr, in 11 patients with chronic stable angina during a randomized, placebo-controlled, double-blind, double crossover trial of four 1-week periods. All patients had a positive exercise test and coronary artery disease prior to entry into the study. Efficacy was assessed weekly by anginal diaries, ambulatory ST segment recordings, and computerized exercise testing 2 to 4 hours after renewal of NTG-TTS. One patient withdrew in the first week (placebo) and was excluded from all analysis. The weekly frequency of anginal attacks was 9 +/- 11 (mean +/- SD) and 9 +/- 10 during the 2 placebo weeks and 11 +/- 14 and 9 +/- 11 during NTG-TTS; the time to 1 mm ST segment depression (seconds) was 268 +/- 178 and 303 +/- 217 with placebo and 228 +/- 221 and 285 +/- 178 with NTG-TTS; exercise duration (seconds) was 375 +/- 230 and 467 +/- 254 during placebo and was 394 +/- 233 and 412 +/- 236 during NTG-TTS. The weekly number of episodes of ST depression was 11 +/- 9 and 8 +/- 5 during placebo and 8 +/- 5 and 9 +/- 7 during NTG-TTS. Our study failed to show any consistent differences in patients treated with placebo or NTG-TTS.
Authors:
P A Crean; P Ribeiro; F Crea; G J Davies; D Ratcliffe; A Maseri
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American heart journal     Volume:  108     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-04     Completed Date:  1985-01-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1494-500     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Aged
Angina Pectoris / drug therapy*,  physiopathology
Blood Pressure / drug effects
Clinical Trials as Topic
Double-Blind Method
Electrocardiography
Exercise Test
Female
Heart Rate / drug effects
Humans
Male
Middle Aged
Nitroglycerin / administration & dosage*,  adverse effects,  therapeutic use
Random Allocation
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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