Document Detail

Failure to raise blood pressure during exercise is a poor prognostic sign in patients with hypertrophic non-obstructive cardiomyopathy.
MedLine Citation:
PMID:  12604864     Owner:  NLM     Status:  MEDLINE    
Sudden cardiac death is a well-documented complication of hypertrophic cardiomyopathy and additionally, failure to raise blood pressure (BP) during exercise has been associated with a poor outcome. The present study group comprised 58 patients with hypertrophic non-obstructive cardiomyopathy (HNCM) who were receiving beta-blocker therapy. All patients underwent submaximal exercise radionuclide ventriculography (RNVG) to evaluate left ventricular (LV) function at both rest and peak exercise. Patients were divided into 2 groups based on the increase in systolic BP during exercise (ie, group A <30% or group N >/=30% of resting systolic BP) and were involved in long-term follow-up (10.4+/-4.0 years). Group A comprised 29% of the subjects. Age and workload at peak exercise were similar in the 2 groups. LV end-diastolic dimension was smaller and the interventricular septum was thicker in group A. LV ejection fraction on RNVG was similar in the 2 groups at rest and at peak exercise. During the follow-up period, more patients in group A than group N suffered syncopal attack (29% vs 5%, p<0.05) and cardiac sudden death (24% vs 2%, p<0.05). Patients with HNCM whose BP fails to rise during exercise have a poor prognosis.
Naoki Isobe; Takuji Toyama; Koichi Taniguchi; Shigeru Oshima; Sachio Kubota; Tadashi Suzuki; Hideki Nagaoka; Hitoshi Adachi; Shigeto Naito; Hiroshi Hoshizaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  67     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-12-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  191-4     Citation Subset:  IM    
Division of Cardiology, Gunma Prefectural Cardiovascular Center, Maebashi, Japan.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Blood Pressure*
Cardiomyopathy, Hypertrophic / diagnosis*,  mortality,  physiopathology*
Cause of Death
Death, Sudden, Cardiac / etiology
Follow-Up Studies
Middle Aged
Radionuclide Ventriculography
Survival Rate
Syncope / etiology
Ventricular Function, Left
Reg. No./Substance:
0/Adrenergic beta-Antagonists

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