Document Detail


Failure to raise blood pressure during exercise is a poor prognostic sign in patients with hypertrophic non-obstructive cardiomyopathy.
MedLine Citation:
PMID:  12604864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sudden cardiac death is a well-documented complication of hypertrophic cardiomyopathy and additionally, failure to raise blood pressure (BP) during exercise has been associated with a poor outcome. The present study group comprised 58 patients with hypertrophic non-obstructive cardiomyopathy (HNCM) who were receiving beta-blocker therapy. All patients underwent submaximal exercise radionuclide ventriculography (RNVG) to evaluate left ventricular (LV) function at both rest and peak exercise. Patients were divided into 2 groups based on the increase in systolic BP during exercise (ie, group A <30% or group N >/=30% of resting systolic BP) and were involved in long-term follow-up (10.4+/-4.0 years). Group A comprised 29% of the subjects. Age and workload at peak exercise were similar in the 2 groups. LV end-diastolic dimension was smaller and the interventricular septum was thicker in group A. LV ejection fraction on RNVG was similar in the 2 groups at rest and at peak exercise. During the follow-up period, more patients in group A than group N suffered syncopal attack (29% vs 5%, p<0.05) and cardiac sudden death (24% vs 2%, p<0.05). Patients with HNCM whose BP fails to rise during exercise have a poor prognosis.
Authors:
Naoki Isobe; Takuji Toyama; Koichi Taniguchi; Shigeru Oshima; Sachio Kubota; Tadashi Suzuki; Hideki Nagaoka; Hitoshi Adachi; Shigeto Naito; Hiroshi Hoshizaki
Related Documents :
22364374 - Does extensive on-water rowing increase muscular strength and endurance?
16923464 - Left ventricular systolic function during stress echocardiography exercise in subjects ...
7717284 - Provocation of latent left ventricular outflow tract gradients with amyl nitrite and ex...
22446724 - Body fat fluctuations among female adolescents with restrained eating behaviours.
23316424 - Muscle activity during knee-extension strengthening exercise performed with elastic tub...
19801034 - Influence of etiology of heart failure on the obesity paradox.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  67     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-12-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  191-4     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Gunma Prefectural Cardiovascular Center, Maebashi, Japan. isobe.n@cvc.pref.gunma.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use
Adult
Aged
Blood Pressure*
Cardiomyopathy, Hypertrophic / diagnosis*,  mortality,  physiopathology*
Cause of Death
Death, Sudden, Cardiac / etiology
Exercise*
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Radionuclide Ventriculography
Survival Rate
Syncope / etiology
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Stent implantation and subsequent dilatation for pulmonary vein stenosis in pediatric patients: maxi...
Next Document:  Therapeutic monitoring of class I antiarrhythmic agents using high-resolution electrocardiography in...