Document Detail

Failure to induce hepatic pathology in animals sensitized to a halothane metabolite and subsequently challenged with halothane.
MedLine Citation:
PMID:  943984     Owner:  NLM     Status:  MEDLINE    
The results of this animal study confirm the induction of delayed hypersensitivity to a halothane metabolite, but the sensitization does not cause hepatic damage on subsequent halothane exposures. Before the hypothesis that hepatic necrosis following halothane has an immunologic basis can be accepted or rejected, more critical studies with different approaches must be made.
J G Reves; L E McCracken
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  55     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:    1976 Mar-Apr
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-42     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal*
Drug-Induced Liver Injury / etiology*,  immunology
Fluoroacetates / adverse effects*
Halothane / adverse effects*,  immunology
Hepatic Encephalopathy / chemically induced,  immunology
Hypersensitivity, Delayed / immunology
Liver / drug effects*
Skin Tests
Trifluoroacetic Acid / adverse effects*
Reg. No./Substance:
0/Fluoroacetates; 151-67-7/Halothane; 76-05-1/Trifluoroacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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