| Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample. | |
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MedLine Citation:
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PMID: 16202394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Linkage studies have confirmed that chromosome 1q23.3 is a susceptibility locus for schizophrenia. It was then claimed that markers at the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) gene showed allelic association with schizophrenia in Canadian families. A second Chinese study found a base pair polymorphism at the CAPON gene also associated with schizophrenia. METHODS: We attempted replication using eight markers from the Canadian study in a UK based sample of 450 cases and 450 supernormal controls. RESULTS: We found no evidence for allelic or haplotypic association with schizophrenia for any of the markers found to be associated in the Canadian sample. CONCLUSIONS: The negative results might reflect genetic heterogeneity between the Canadian, Chinese and UK samples or be due to methodological problems. The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations. |
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Authors:
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Vinay Puri; Andrew McQuillin; Srinivasa Thirumalai; Jacob Lawrence; Robert Krasucki; Khalid Choudhury; Susmita Datta; Simon Kerwin; Digby Quested; Nicholas Bass; Jonathan Pimm; Graham Lamb; Helen Moorey; Gomathinayagam Kandasami; Allison Badacsonyi; Katie Kelly; Jenny Morgan; Bhaskar Punukollu; Haitham Nadeem; David Curtis; Hugh M D Gurling |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-10-03 |
Journal Detail:
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Title: Biological psychiatry Volume: 59 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-24 Completed Date: 2006-03-09 Revised Date: 2007-05-24 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 195-7 Citation Subset: IM |
Affiliation:
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Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, London, W1T 4JF, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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genetics* Adult Chromosomes, Human, Pair 1* Female Genetic Predisposition to Disease / genetics* Great Britain Humans Linkage Disequilibrium Lod Score Male Microsatellite Repeats / genetics Middle Aged Polymorphism, Single Nucleotide / genetics Reference Values Schizophrenia / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/NOS1AP protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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