Document Detail


Failure of stroke volume augmentation during exercise and dobutamine stress is unrelated to load-independent indexes of right ventricular performance after the Mustard operation.
MedLine Citation:
PMID:  11082379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Impaired right ventricular function has been implicated as a cause of reduced maximal exercise capacity after the Mustard operation for transposition of the great arteries. METHODS AND RESULTS: Fourteen asymptomatic survivors of the Mustard operation were studied. Each underwent conventional cardiac catheterization, and after satisfactory hemodynamics were confirmed, load-independent indexes of ventricular function were derived by conductance catheter during dobutamine infusion (0, 5, and 10 microg x kg(-1) x min(-1)). Seven patients also underwent upright exercise testing on a bicycle ergometer with analysis of respiratory gas exchange by continuous mass spectrometry. Accessible pulmonary blood flow was measured at each workload with an automated acetylene rebreathing technique. All patients exercised to a satisfactory end point (respiratory quotient >1.1). Maximum oxygen consumption during exercise was impaired compared with predicted values (mean, 77%; P:<0.02). Both exercise and dobutamine infusion were associated with an increase in cardiac index and heart rate and a reduced stroke volume index response. This was despite significantly improved indexes of myocardial contraction (end-systolic pressure volume relation, P:<0.001), preload recruitable stroke work index (P:<0.01), VA coupling (P:<0.001), and isovolumic relaxation (P:<0.001) during dobutamine infusion. There were no changes observed in end-diastolic pressure-volume relations, but there was failure to augment ventricular filling manifest by absence of change in dV/dt (P:=NS). CONCLUSIONS: The stroke volume response to exercise stress is reduced in patients after the Mustard operation. A similar failure to augment stroke volume occurs during dobutamine stress despite appropriate responses in load-independent indexes of contraction and relaxation. This is due to failure to augment right ventricular filling rates during tachycardia, presumably as a result of impaired AV transport, consequent to the abnormal intra-atrial pathways.
Authors:
G P Derrick; I Narang; P A White; A Kelleher; A Bush; D J Penny; A N Redington
Related Documents :
3793669 - Oral opc-8212 for the treatment of congestive heart failure: hemodynamic improvement an...
17281499 - Cancellation of respiratory artifact in impedance cardiography.
11052859 - Comparison of the prognostic value of left ventricular filling and peak oxygen uptake i...
15629509 - Cardiac alterations in cirrhosis: reversibility after liver transplantation.
6315259 - Comparative effects of propranolol and verapamil alone and in combination on left ventr...
1191449 - Effects of sustained isometric handgrip on praecordial accelerocardiogram in normal sub...
10710129 - The positive inotropic effects of milrinone but not of digoxin are attenuated at short ...
12509499 - The time course and direction of lower limb vascular conductance changes during volunta...
18685529 - The effect of aerobic exercise on neutrophil functions.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  102     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-22     Completed Date:  2000-12-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  III154-9     Citation Subset:  IM    
Affiliation:
Great Ormond Street Hospital for Children, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cardiac Surgical Procedures / adverse effects*
Cardiotonic Agents / diagnostic use
Child, Preschool
Dobutamine / diagnostic use
Exercise Test
Female
Heart Function Tests
Heart Rate
Hemodynamics
Humans
Infant
Injections, Intra-Arterial
Male
Myocardial Contraction
Oxygen Consumption
Physical Exertion*
Stroke Volume*
Transposition of Great Vessels / surgery*
Ventricular Dysfunction, Right / etiology*,  physiopathology*
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of respiration and gravity on infradiaphragmatic venous flow in normal and Fontan patients.
Next Document:  Surgical management of mitral regurgitation after repair of endocardial cushion defects: early and m...