Document Detail

Failure of prophylactic surgery to avert massive pituitary expansion in pregnancy.
MedLine Citation:
PMID:  3791672     Owner:  NLM     Status:  MEDLINE    
Macroprolactinomas have a well-recognized potential for marked expansion during pregnancy. Measures advocated to minimize this risk include prior treatment with dopamine agonists, radiotherapy and pituitary surgery. We describe a patient who underwent transsphenoidal surgery with the removal of an histologically proven prolactin-secreting adenoma with the intention of rendering subsequent pregnancy safe. The patient remained hyperprolactinaemic and received prolonged therapy with metergoline and bromocriptine which suppressed prolactin to normal and she conceived after induction of ovulation with human menopausal gonadotrophin and human chorionic gonadotrophin. At 3 months gestation she developed headaches, vomiting, reduced visual acuity and bitemporal hemianopia caused by massive pituitary expansion. Reintroduction of bromocriptine rapidly abolished features of tumour expansion and after delivery of a full-term normal female infant, repeat CT scan documented tumour shrinkage.
P E Belchetz; A Carty; L G Clearkin; J C Davis; R V Jeffreys; P G Rae
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  25     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1987-02-05     Completed Date:  1987-02-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  325-30     Citation Subset:  IM    
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MeSH Terms
Bromocriptine / therapeutic use
Pituitary Gland / surgery
Pituitary Neoplasms / drug therapy,  secretion*,  surgery
Pregnancy Complications, Neoplastic / surgery*
Prolactin / secretion*
Reg. No./Substance:
25614-03-3/Bromocriptine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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