Document Detail


Failure of physiologic doses of pure UVA or UVB to induce lesions in photosensitive cutaneous lupus erythematosus: implications for phototesting.
MedLine Citation:
PMID:  17100736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Phototesting studies in cutaneous lupus erythematosus have yielded variable results, with most trials reporting photo-induction of lesions by both UVA and UVB in substantial numbers of patients.
OBJECTIVES: To determine the minimal erythema dose in patients with subacute cutaneous lupus erythematosus (SCLE) and controls.
PATIENTS/METHODS: We phototested nine patients with SCLE and 14 skin type-matched controls, using repetitive dosing of UVA1 and UVB, but with filters that removed most of the shorter UVC and longer infrared and visible light. In addition, DNA was isolated from anticoagulated blood to genotype the TNF-alpha 308 region in each patient and control.
RESULTS: We were unable to demonstrate a difference in minimal erythema dose (MED) between patients and controls, or any correlation of MED with either TNF genotype or systemic drug therapy for SCLE. In addition, no SCLE skin lesions were induced in the nine patients with either UVA or UVB, and one patient cleared a skin lesion after low-dose UVA1 irradiation.
CONCLUSIONS: The potential role of wavelengths outside the UVA and UVB range in the photo-induction of cutaneous lupus skin lesions needs to be investigated, and there is a need to standardize phototesting equipment and procedures for patients with cutaneous lupus erythematous.
Authors:
Michele L Lokitz; Sara Billet; Purvisha Patel; Eun Ji Kwon; Robert M Sayre; Kathleen E Sullivan; Victoria P Werth
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Photodermatology, photoimmunology & photomedicine     Volume:  22     ISSN:  0905-4383     ISO Abbreviation:  Photodermatol Photoimmunol Photomed     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-14     Completed Date:  2007-02-15     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  9013641     Medline TA:  Photodermatol Photoimmunol Photomed     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  290-6     Citation Subset:  IM    
Affiliation:
The University of Pennsylvania, Philadelphia, PA, USA.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Female
Humans
Lupus Erythematosus, Cutaneous / diagnosis*,  pathology
Male
Photosensitivity Disorders / diagnosis*,  pathology
Predictive Value of Tests
Radiation Dosage
Skin Physiological Phenomena / radiation effects
Skin Tests / standards*
Ultraviolet Rays / diagnostic use*
Grant Support
ID/Acronym/Agency:
1K24AR002207/AR/NIAMS NIH HHS; K24 AR002207/AR/NIAMS NIH HHS; K24-AR 02207/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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