| Failure of immunosuppression to prolong venous allograft survival. | |
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MedLine Citation:
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PMID: 7350895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of allograft veins in vascular reconstruction remains ill defined. The present experiment was undertaken to evaluate the role of immunosuppression in maintaining allograft patency in the canine femoral venous circulation. Twenty-seven mongrel dogs had segments of both femoral veins excised and each dog received one allograft and one autograft. The dogs were randomly assigned to a control group or to one of three treatment regimens of azathioprine. Low doses of azathioprine were of no benefit in improving patency of venous alografts. Microscopic evaluation of these grafts suggests that substantial intimal repopulation by host cells occurs by six to eight weeks in the canine model. Other methods of preserving patency until intimal repopulation occurs deserve further investigation. |
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Authors:
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J J Ricotta; G J Collins; N M Rich; D G Reynolds |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 115 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1980 Jan |
Date Detail:
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Created Date: 1980-02-26 Completed Date: 1980-02-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 99-101 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Azathioprine / therapeutic use* Dogs Female Femoral Vein / transplantation, ultrastructure Graft Survival / drug effects Immunosuppression* Postoperative Complications / prevention & control* Thrombophlebitis / prevention & control* Thrombosis / prevention & control Transplantation, Autologous Transplantation, Homologous Veins / transplantation* |
| Chemical | |
Reg. No./Substance:
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446-86-6/Azathioprine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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