Document Detail


Failure of hypoxic pulmonary vasoconstriction in the canine asthma model. Effect of prostaglandin inhibitors.
MedLine Citation:
PMID:  659609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measurements of respiratory mechanics, arterial blood gases, and pulmonary vascular resistance were made before and 15 min after inhalation challenge with Ascaris suum extract in dogs with natural sensitivity to this antigen. 25 of 47 dogs were treated before inhalation challenge with a prostaglandin inhibitor (90 mg/kg of aspirin or 2 mg/kg of indomethacin by intravenous infusion). In response to the challenge, bronchospasm developed in approximately half (responders) of each group reflected by decreases in mean specific respiratory system conductance and arterial oxygen tension. While the dogs were breathing room air, pulmonary vascular resistance remained unchanged after antigen challenge in the responders not given aspirin or indomethacin, but increased significantly and was associated with a lesser degree of arterial hypoxemia in the responders pretreated with either of the prostaglandin inhibitors. Prevention of arterial hypoxemia by oxygen breathing blocked an increase in pulmonary vascular resistance in four pretreated responders. No changes in respiratory mechanics, pulmonary hemodynamics, or arterial blood gases were noted in the 21 dogs who did not develop bronchospasm regardless of whether or not they were pretreated. 12 additional dogs in whom arterial hypoxemia was produced by 10% oxygen breathing, showed an increase in pulmonary vascular resistance that was not potentiated by pretreatment with aspirin in 6. We conclude that in acute experimental canine asthma, vasodilator prostaglandins appear to blunt the hypoxic pulmonary vasoconstrictor response, thereby further compromising gas exchange but preventing the development of pulmonary hypertension.
Authors:
M A Cohn; H Baier; A Wanner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  61     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-08-28     Completed Date:  1978-08-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1463-70     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / physiopathology
Ascaris / immunology
Aspirin / pharmacology
Asthma / etiology,  physiopathology*
Dogs
Hypersensitivity / complications,  physiopathology
Indomethacin / pharmacology
Lung / blood supply*
Oxygen / pharmacology
Prostaglandin Antagonists / pharmacology*
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
0/Prostaglandin Antagonists; 50-78-2/Aspirin; 53-86-1/Indomethacin; 7782-44-7/Oxygen
Comments/Corrections

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