| Failure of haemodynamic measurements to predict recurrent gastrointestinal bleeding in cirrhotic patients receiving propranolol. | |
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MedLine Citation:
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PMID: 3500973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an attempt to identify the haemodynamic factors predicting the recurrence of gastrointestinal bleeding in cirrhotic patients receiving propranolol, haemodynamic measurements were prospectively collected. Systemic and splanchnic haemodynamics were assessed before propranolol administration. Among 77 patients receiving propranolol, 24 re-bled and 53 did not re-bleed in a follow-up period of 30-730 days (median 540). There was no difference between patients with and without recurrent bleeding with regard to the initial value of heart rate, mean arterial pressure, cardiac index, and hepatic venous pressure gradient. A subgroup of 43 patients was further investigated for the haemodynamic response to one single dose of 40 mg of propranolol. No difference was observed in the propranolol-induced changes of heart rate, mean arterial pressure, cardiac index or hepatic venous pressure gradient, between patients with (n = 14) and those without (n = 29) recurrent bleeding while taking propranolol. In conclusion, systemic haemodynamics and hepatic venous pressure gradient have no predictive value in evaluating the risk of recurrent bleeding in cirrhotic patients receiving propranolol. Furthermore, therapeutic efficacy of propranolol cannot be predicted from the haemodynamic response to a single first dose of this substance. |
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Authors:
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D Valla; M I Jiron; T Poynard; A Braillon; D Lebrec |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hepatology Volume: 5 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1988-02-20 Completed Date: 1988-02-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 144-8 Citation Subset: IM |
Affiliation:
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Unité de Recherches de Physiopathologie Hépatique (INSERM U 24), Hôpital Beaujon, Clichy, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Gastrointestinal Hemorrhage / diagnosis, etiology*, physiopathology Heart Rate Hemodynamics* Humans Liver Cirrhosis / complications*, drug therapy, physiopathology Middle Aged Prospective Studies Recurrence |
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