| Failure of glucose and branched-chain amino acids to normalize brain glucose use in portacaval shunted rats. | |
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MedLine Citation:
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PMID: 2428933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several abnormalities in brain and plasma amino acid concentrations caused by portacaval shunting in rats return toward normal after 4 days of intravenous infusion with either glucose or glucose with branched-chain amino acids. To assess the effect of such treatment on brain energy metabolism, regional brain glucose use was measured using [14C]glucose and autoradiography, 5 weeks after portacaval shunting. In one experiment intravenous glucose or glucose with branched-chain amino acids was given for 4 days. In a separate experiment the treatment was given orally for 2 weeks, and in addition to glucose use, brain monoamines and amino acids were measured. No other food was provided; the rats had free access to water. Normally fed shunted rats and sham-operated rats served as controls. Both types of oral treatment lowered the high concentrations of tyrosine, phenylalanine, and glutamine in plasma and brain. Glucose without amino acids normalized brain tryptophan. Levels of brain norepinephrine, 5-hydroxytryptamine (serotonin), and 5-hydroxyindoleacetic acid were significantly raised after shunting. Treatment had no effect on norepinephrine but the glucose diet brought the indoles into the normal range. In contrast, neither intravenous nor oral treatment affected brain glucose use, which remained depressed by 25-30% in all brain areas examined. |
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Authors:
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A M Mans; D W Davis; J F Biebuyck; R A Hawkins |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neurochemistry Volume: 47 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1986-11-19 Completed Date: 1986-11-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1434-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood Amino Acids, Branched-Chain / pharmacology* Animals Brain / drug effects, metabolism* Dopamine / blood Glucose / metabolism*, pharmacology* Hydroxyindoleacetic Acid / blood Liver Diseases / metabolism Male Metabolic Clearance Rate Norepinephrine / blood Portacaval Shunt, Surgical* Rats Serotonin / blood |
| Grant Support | |
ID/Acronym/Agency:
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NS 16389/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Amino Acids, Branched-Chain; 50-67-9/Serotonin; 50-99-7/Glucose; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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