Document Detail

Failure of glucagon release in infants of diabetic mothers.
MedLine Citation:
PMID:  4653874     Owner:  NLM     Status:  MEDLINE    
Two hours after birth 30 normal infants had a fall in blood glucose of 20.6 mg/100 ml and a rise of plasma pancreatic glucagon of 50.7 pg/ml. Fifteen infants of diabetic mothers treated with insulin had a much greater fall in blood glucose of 77.5 mg/100 ml and a smaller rise of glucagon of 20.9 pg/ml. By comparison 14 small-for-dates infants, who are also prone to hypoglycaemia, had a blood glucose fall of 32.8 mg/100 ml and a larger rise of pancreatic glucagon of 96.0 pg/ml. It is suggested that the impaired pancreatic glucagon rise in the infants of diabetic mothers may be a significant factor in their hypoglycaemia.
S R Bloom; D I Johnston
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  4     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1972 Nov 
Date Detail:
Created Date:  1973-04-25     Completed Date:  1973-04-25     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  453-4     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight
Blood Glucose
Glucagon / blood,  metabolism*
Hypoglycemia / etiology
Infant, Newborn
Infant, Newborn, Diseases* / blood
Insulin / adverse effects,  therapeutic use
Metabolic Diseases* / blood
Pregnancy in Diabetics* / drug therapy
Time Factors
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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