Document Detail

Failure of the emergency contraceptive levonorgestrel and the risk of adverse effects in pregnancy and on fetal development: an observational cohort study.
MedLine Citation:
PMID:  16084867     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine pregnancy and neonatal outcome after the failure of levonorgestrel as an emergency contraceptive. DESIGN: A retrospective observational cohort study. SETTING: Telephone consultations concerning reproductive risk factors conducted by Telefono Rosso-Teratology Information Service, Catholic University of Sacred Heart, Rome, Italy. PATIENT(S): Women exposed to levonorgestrel (36 cases) compared with a control group (80 cases). INTERVENTION(S): Teratological counseling. MAIN OUTCOME MEASURE(S): The rate of congenital anomalies, the prepartum or peripartum complications, and the pregnancy outcomes. RESULT(S): Twenty-five exposed newborns with length and weight identical to that of the control group were shown to be without increased risk of congenital malformation. No statistical differences were observed in terms of spontaneous or legal abortion and pregnancy and neonatal complications, and there was no ectopic pregnancy in either group. CONCLUSION(S): Although the sample size was small, in our experience, the failure of levonorgestrel as an emergency contraceptive was not associated with an increased risk of major congenital malformations, prepartum or peripartum complications, or an adverse pregnancy outcome.
Marco De Santis; Anna Franca Cavaliere; Gianluca Straface; Brigida Carducci; Alessandro Caruso
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  84     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-08     Completed Date:  2005-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296-9     Citation Subset:  IM    
Telefono Rosso, Teratology Information Service, Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy.
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MeSH Terms
Cohort Studies
Contraceptives, Oral, Synthetic / adverse effects,  pharmacology*
Fetal Development / drug effects*,  physiology
Infant, Newborn
Levonorgestrel / adverse effects,  pharmacology*
Pregnancy Outcome / epidemiology
Retrospective Studies
Risk Factors
Treatment Failure
Reg. No./Substance:
0/Contraceptives, Oral, Synthetic; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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