Document Detail

Failure of carnitine in improving hepatic nitrogen content in alcoholic and non-alcoholic malnourished rats.
MedLine Citation:
PMID:  21049216     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate the effect of carnitine supplementation on alcoholic malnourished rats' hepatic nitrogen content.
METHODS: Malnourished rats, on 50% protein-calorie restriction with free access to water (malnutrition group) and malnourished rats under the same conditions with free access to a 20% alcohol/water solution (alcohol group) were studied. After the undernourishment period (4 weeks with or without alcohol), both groups were randomly divided into two subgroups, one of them nutritionally recovered for 28 days with free access to a normal diet and water (recovery groups) and the other re-fed with free access to diet and water plus carnitine (0.1 g/g body weight/day by gavage) (carnitine groups). No alcohol intake was allowed during the recovery period.
RESULTS: The results showed: i) no difference between the alcohol/no alcohol groups, with or without carnitine, regarding body weight gain, diet consumption, urinary nitrogen excretion, plasma free fatty acids, lysine, methionine, and glycine. ii) Liver nitrogen content was highest in the carnitine recovery non-alcoholic group (from 1.7 to 3.3 g/100 g, P<0·05) and lowest in alcoholic animals (about 1.5 g/100g). iii) Hepatic fat content (~10 g/100 g, P>·05) was highest in the alcoholic animals.
CONCLUSION: Carnitine supplementation did not induce better nutritional recovery.
Luciana P Rodrigues; Guilherme Vannucchi Portari; Gilberto João Padovan; Alceu Afonso Jordão; Vivian Suen; Julio Sergio Marchini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  65     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-04     Completed Date:  2011-04-06     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  877-83     Citation Subset:  IM    
Universidade de São Paulo, SP, Brazil.
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MeSH Terms
Alcoholism / complications*
Carnitine / therapeutic use*
Dietary Supplements
Ethanol / blood
Fatty Acids, Nonesterified / blood
Fatty Liver / metabolism
Liver / chemistry*,  drug effects
Nitrogen / analysis*
Protein-Energy Malnutrition / blood,  drug therapy*,  etiology
Random Allocation
Rats, Wistar
Vitamin B Complex / therapeutic use*
Weight Gain / drug effects
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 12001-76-2/Vitamin B Complex; 541-15-1/Carnitine; 64-17-5/Ethanol; 7727-37-9/Nitrogen

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