| Failure of calcium antagonistic agents to prevent hepatotoxicity induced by diclofenac. | |
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MedLine Citation:
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PMID: 8532609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diclofenac (0.5-2 mM) dose- and time-dependently reduces the viability of isolated hepatocytes. This effect cannot be counteracted by the calcium channel blockers diltiazem (0.05-0.1 mM) and verapamil (0.05-0.5 mM), the calmodulin antagonist calmidazolium (0.01 mM) or Quin 2-AM (0.1 mM), an intracellular calcium chelating agent. On the contrary, verapamil even accentuates the toxic effects of diclofenac. It is concluded from these results, that diclofenac causes cell damage by other mechanisms than calcium overload. |
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Authors:
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G Schmitz; H Lepper; C J Estler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology & toxicology Volume: 77 ISSN: 0901-9928 ISO Abbreviation: Pharmacol. Toxicol. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1996-01-29 Completed Date: 1996-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8702180 Medline TA: Pharmacol Toxicol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 32-5 Citation Subset: IM |
Affiliation:
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Institute for Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Anti-Inflammatory Agents, Non-Steroidal / antagonists & inhibitors, toxicity* Calcium Channel Blockers / pharmacology* Cell Survival / drug effects Cells, Cultured Chelating Agents / pharmacology Diclofenac / antagonists & inhibitors, toxicity* Diltiazem / pharmacology Dose-Response Relationship, Drug Drug Interactions Liver / cytology, drug effects* Male Rats Rats, Wistar Verapamil / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Calcium Channel Blockers; 0/Chelating Agents; 15307-86-5/Diclofenac; 42399-41-7/Diltiazem; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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