| Failure of ascrobic acid to inhibit the metabolic N-oxidation of the bladder carcingen 4-biphenylamine. | |
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MedLine Citation:
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PMID: 841184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of L-ascorbic acid on the in vivo metabolic N-oxidation of the bladder carcinogen 4-biphenylamine has been investigated in the dog. Gas chromatographic analysis of the urines of dogs receiving concomitant oral doses of L-ascorbic acid and 4-biphyenylamine showed no significant difference in the N-oxidized metabolites when compared to dogs receiving arylamine alone. The results indicate that pretreatment with large doses of L-ascorbic acid has no effect on the metabolic N-oxidation of 4-biphenylamine or on the urinary concentration of these metabolites. The failure of L-ascrobic acid to lower the urinary concentration of these presumed proximate urinary carcinogens casts doubt on its efficacy in bladder tumor prophylaxis. |
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Authors:
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E Brill; J L Radomski |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Research communications in chemical pathology and pharmacology Volume: 16 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1977 Jan |
Date Detail:
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Created Date: 1977-04-15 Completed Date: 1977-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 85-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminobiphenyl Compounds
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metabolism*,
urine Animals Ascorbic Acid / pharmacology* Carcinogens / metabolism* Chromatography, Gas Depression, Chemical Dogs Female Male Nitroso Compounds / urine Oxidation-Reduction Urinary Bladder / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Aminobiphenyl Compounds; 0/Carcinogens; 0/Nitroso Compounds; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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