Document Detail


Failure of ascrobic acid to inhibit the metabolic N-oxidation of the bladder carcingen 4-biphenylamine.
MedLine Citation:
PMID:  841184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of L-ascorbic acid on the in vivo metabolic N-oxidation of the bladder carcinogen 4-biphenylamine has been investigated in the dog. Gas chromatographic analysis of the urines of dogs receiving concomitant oral doses of L-ascorbic acid and 4-biphyenylamine showed no significant difference in the N-oxidized metabolites when compared to dogs receiving arylamine alone. The results indicate that pretreatment with large doses of L-ascorbic acid has no effect on the metabolic N-oxidation of 4-biphenylamine or on the urinary concentration of these metabolites. The failure of L-ascrobic acid to lower the urinary concentration of these presumed proximate urinary carcinogens casts doubt on its efficacy in bladder tumor prophylaxis.
Authors:
E Brill; J L Radomski
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  16     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-04-15     Completed Date:  1977-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminobiphenyl Compounds / metabolism*,  urine
Animals
Ascorbic Acid / pharmacology*
Carcinogens / metabolism*
Chromatography, Gas
Depression, Chemical
Dogs
Female
Male
Nitroso Compounds / urine
Oxidation-Reduction
Urinary Bladder / drug effects*
Chemical
Reg. No./Substance:
0/Aminobiphenyl Compounds; 0/Carcinogens; 0/Nitroso Compounds; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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