Document Detail

Failure of anti-MHC antibodies to prevent GVHD in DLA mismatched unrelated canine marrow recipients.
MedLine Citation:
PMID:  2297589     Owner:  NLM     Status:  MEDLINE    
Gene products of the major histocompatibility complex (MHC) have been shown to elicit lethal graft-versus-host disease (GVHD) in experimental animals. Antibodies specific for MHC cell surface determinants might therefore be expected to overcome histocompatibility barriers and influence survival of marrow graft recipients. GVHD can be consistently induced in dogs by transplanting donor marrow cells into lethally irradiated, unrelated, mismatched recipients. Three anti-Ia monoclonal antibodies were administered to five canine recipients, each at a dose of 0.2 mg/kg body weight per day intravenously for 10 days, beginning on day 0, the day of transplantation. Eight canine recipients were treated with antidog alloantiserum 10 ml/kg body weight per day intravenously on days -2 to day +20, in addition to receiving postgrafting methotrexate. The antiserum was generated by immunizing a matched littermate of the donor with peripheral blood cells of the recipient before transplantation. Survival was no different in the two groups of dogs, compared with historical controls without antibody treatment. A possible explanation for the failure of anti-MHC antibodies to modify acute GVHD in the dog is the inability of antibody to reach critical tissue sites targeted in GVHD.
W C Ladiges; R Storb; R F Raff; F R Appelbaum; B Sandmaier; F Schuening; T Graham
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  5     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-05     Completed Date:  1990-03-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA.
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MeSH Terms
Bone Marrow Transplantation / immunology*
Disease Models, Animal
Graft vs Host Disease / prevention & control*
Histocompatibility Antigens
Histocompatibility Antigens Class I*
Histocompatibility Antigens Class II
Isoantibodies / administration & dosage*
Transplantation, Homologous
Grant Support
Reg. No./Substance:
0/Histocompatibility Antigens; 0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II; 0/Isoantibodies; 0/histocompatibility antigen DLA

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