| Failure of aminophylline and salbutamol to improve respiratory muscle function and exercise tolerance in healthy humans. | |
MedLine Citation:
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PMID: 2595106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effects of intravenously administered aminophylline (A; 6 mg/kg over 20 min, followed by 0.9 mg/kg/h), salbutamol (S; 4 micrograms/kg over 20 min, followed by 3 micrograms/kg/h) and placebo (P; saline solution) on the strength of the respiratory muscles, the ventilatory endurance and the exercise tolerance in 7 healthy humans. Neither A nor S caused bronchodilation, as shown by the lack of change in FEV1. The strength of respiratory muscles, as measured by maximal inspiratory pressure (MIP), and the ventilatory endurance, as measured by sustainable inspiratory pressure (SIP), were not statistically different after A (MIP: 136.5 +/- SE 11.6 cm H2O; SIP: 104.2 +/- 8.4 cm H2O or after S (MIP: 135.7 +/- 11.5; SIP: 107.1 +/- 10.4) compared to after P (MIP: 127.1 +/- 10.1; SIP: 105.0 +/- 5.9). Significant changes in 12-min walking distance, perceived exertion rate, anaerobic threshold, maximal work output, maximal O2 uptake were observed neither after A nor after S. The exchange ratio and heart rate were higher after A and S than after P at some steps of a progressive, symptom-limited, treadmill-based exercise test. This might be the result of metabolic or cardiovascular adaptations elicited by these drugs. We conclude that A or S at therapeutic concentrations have no clinically relevant beneficial effects on ventilatory muscle function and exercise tolerance in healthy subjects. |
Authors:
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B Violante; R Pellegrino; C Vinay; R Selleri; G Ghinamo |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Respiration; international review of thoracic diseases Volume: 55 ISSN: 0025-7931 ISO Abbreviation: Respiration Publication Date: 1989 |
Date Detail:
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Created Date: 1990-01-17 Completed Date: 1990-01-17 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0137356 Medline TA: Respiration Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 227-36 Citation Subset: IM; S |
Affiliation:
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Servizio di Fisiopatologia Respiratoria, Ospedale A. Carle, Cuneo, Italia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albuterol / pharmacology* Aminophylline / pharmacology* Exercise / physiology* Exercise Test Humans Male Physical Endurance / drug effects Pulmonary Gas Exchange / drug effects Respiratory Muscles / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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18559-94-9/Albuterol; 317-34-0/Aminophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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