Document Detail

Failure of aminophylline and salbutamol to improve respiratory muscle function and exercise tolerance in healthy humans.
MedLine Citation:
PMID:  2595106     Owner:  NLM     Status:  MEDLINE    
We investigated the effects of intravenously administered aminophylline (A; 6 mg/kg over 20 min, followed by 0.9 mg/kg/h), salbutamol (S; 4 micrograms/kg over 20 min, followed by 3 micrograms/kg/h) and placebo (P; saline solution) on the strength of the respiratory muscles, the ventilatory endurance and the exercise tolerance in 7 healthy humans. Neither A nor S caused bronchodilation, as shown by the lack of change in FEV1. The strength of respiratory muscles, as measured by maximal inspiratory pressure (MIP), and the ventilatory endurance, as measured by sustainable inspiratory pressure (SIP), were not statistically different after A (MIP: 136.5 +/- SE 11.6 cm H2O; SIP: 104.2 +/- 8.4 cm H2O or after S (MIP: 135.7 +/- 11.5; SIP: 107.1 +/- 10.4) compared to after P (MIP: 127.1 +/- 10.1; SIP: 105.0 +/- 5.9). Significant changes in 12-min walking distance, perceived exertion rate, anaerobic threshold, maximal work output, maximal O2 uptake were observed neither after A nor after S. The exchange ratio and heart rate were higher after A and S than after P at some steps of a progressive, symptom-limited, treadmill-based exercise test. This might be the result of metabolic or cardiovascular adaptations elicited by these drugs. We conclude that A or S at therapeutic concentrations have no clinically relevant beneficial effects on ventilatory muscle function and exercise tolerance in healthy subjects.
B Violante; R Pellegrino; C Vinay; R Selleri; G Ghinamo
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  55     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1989  
Date Detail:
Created Date:  1990-01-17     Completed Date:  1990-01-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  227-36     Citation Subset:  IM; S    
Servizio di Fisiopatologia Respiratoria, Ospedale A. Carle, Cuneo, Italia.
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MeSH Terms
Albuterol / pharmacology*
Aminophylline / pharmacology*
Exercise / physiology*
Exercise Test
Physical Endurance / drug effects
Pulmonary Gas Exchange / drug effects
Respiratory Muscles / drug effects*,  physiology
Reg. No./Substance:
18559-94-9/Albuterol; 317-34-0/Aminophylline

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