Document Detail

Failure of the TRH test to predict the clinical course of patients in remission after antithyroid drug therapy for Graves' disease.
MedLine Citation:
PMID:  104514     Owner:  NLM     Status:  MEDLINE    
In an attempt to assess the predictive value of the TRH test in patients in remission after stopping antithyroid drugs for thyrotoxicosis, 11 euthyroid patients with a subnormal (group I) and 23 euthyroid patients with a normal serum TSH response to TRH (group II) were followed-up for one year. The mean +/- SE intervals since the withdrawal of drug therapy were 23.2 +/- 1.6 and 20.4 +/- 0.7 months, respectively, at the outset of the study. Five patients (45%) from group I and 7 patients (30%) from group II relapsed during the period of observation. In addition, a change from a subnormal TSH response to TRH and vice versa occurred in some patients. It is not possible to predict by means of the TRH test the subsequent clinical course of patients in remission following antithyroid drug therapy.
W J Irvine; R S Gray; A D Toft; J Seth; E H Cameron
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  90     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-03-13     Completed Date:  1979-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  18-22     Citation Subset:  IM    
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MeSH Terms
Carbimazole / therapeutic use
Evaluation Studies as Topic
Follow-Up Studies
Graves Disease / drug therapy*
Remission, Spontaneous
Thyrotropin / blood
Thyrotropin-Releasing Hormone / diagnostic use*
Reg. No./Substance:
22232-54-8/Carbimazole; 24305-27-9/Thyrotropin-Releasing Hormone; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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