Document Detail

Failure of Saccharomyces boulardii to hydrolyse bile acids in vitro.
MedLine Citation:
PMID:  7854196     Owner:  NLM     Status:  MEDLINE    
The bile acid deconjugating capacity of Saccharomyces boulardii was tested in isolated culture and in co-culture upon the bile acid metabolizing capacity of Bacteroides fragilis. S. boulardii was grown over 60 h in plain brain heart infusion (BHI) broth and in the presence of either 2 mM glycocholic or glycochenodeoxycholic acid under both aerobic and anaerobic conditions. S. boulardii did not metabolize either glycocholic acid or glycochenodeoxycholic acid. S. boulardii and B. fragilis were grown anaerobically together in BHI broth supplemented with either 0.1 mM glycholic acid or 0.1 mM glycochenodeoxycholic acid. When S. boulardii and B. fragilis were anaerobically co-cultured, S. boulardii did not alter the bile acid metabolism of B. fragilis. Specifically primary and conjugated bile acids decreased over time, while keto bile acids and free bile acids increased. S. boulardii not only fails to metabolize primary conjugated bile acids but it does not enhance or inhibit the bile acid metabolism of B. fragilis when the organisms are co-cultured in anaerobic medium.
A A ElHennawy; C T Wong; S A Kocoshis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Microbios     Volume:  80     ISSN:  0026-2633     ISO Abbreviation:  Microbios     Publication Date:  1994  
Date Detail:
Created Date:  1995-03-13     Completed Date:  1995-03-13     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0207257     Medline TA:  Microbios     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  IM    
Department of Pediatrics, Children's Hospital of Pittsburgh, Pennsylvania.
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MeSH Terms
Bacteroides fragilis / growth & development,  metabolism*
Bile Acids and Salts / metabolism*
Chromatography, Gas
Glycochenodeoxycholic Acid
Saccharomyces / growth & development,  metabolism*
Reg. No./Substance:
0/Bile Acids and Salts; 640-79-9/Glycochenodeoxycholic Acid

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