| Failure of resolution of portal fibrosis during omega-3 fatty acid lipid emulsion therapy in two patients with irreversible intestinal failure. | |
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MedLine Citation:
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PMID: 20105644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Parenteral omega-3 fatty acid lipid emulsions have been evaluated for their potential role in reversing intestinal failure-associated liver disease. We report our experience using Omegaven in 2 patients with irreversible intestinal failure and intestinal failure-associated liver disease. Despite biochemical and histologic improvement in cholestasis, both patients had persisting, significant portal fibrosis on liver biopsy. |
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Authors:
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Jason S Soden; Mark A Lovell; Kristin Brown; David A Partrick; Ronald J Sokol |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 156 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-28 Completed Date: 2010-02-23 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 327-31 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado Denver School of Medicine and The Children's Hospital, 13123 E 16th Ave, Box B290, Aurora, CO 80045, USA. soden.jason@tchden.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fat Emulsions, Intravenous
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therapeutic use* Fatty Acids, Omega-3 / therapeutic use* Female Hirschsprung Disease / therapy* Humans Infant, Newborn Intestinal Diseases / therapy* Liver Cirrhosis, Biliary / pathology, therapy* Male Parenteral Nutrition / adverse effects, methods* Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous; 0/Fatty Acids, Omega-3 |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2010 Sep;157(3):517; author reply 518
[PMID:
20584532
]
J Pediatr. 2011 Jul;159(1):170-1 [PMID: 21669322 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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