Document Detail

Failure of resolution of portal fibrosis during omega-3 fatty acid lipid emulsion therapy in two patients with irreversible intestinal failure.
MedLine Citation:
PMID:  20105644     Owner:  NLM     Status:  MEDLINE    
Parenteral omega-3 fatty acid lipid emulsions have been evaluated for their potential role in reversing intestinal failure-associated liver disease. We report our experience using Omegaven in 2 patients with irreversible intestinal failure and intestinal failure-associated liver disease. Despite biochemical and histologic improvement in cholestasis, both patients had persisting, significant portal fibrosis on liver biopsy.
Jason S Soden; Mark A Lovell; Kristin Brown; David A Partrick; Ronald J Sokol
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  156     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-02-23     Revised Date:  2011-08-03    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado Denver School of Medicine and The Children's Hospital, 13123 E 16th Ave, Box B290, Aurora, CO 80045, USA.
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MeSH Terms
Fat Emulsions, Intravenous / therapeutic use*
Fatty Acids, Omega-3 / therapeutic use*
Hirschsprung Disease / therapy*
Infant, Newborn
Intestinal Diseases / therapy*
Liver Cirrhosis, Biliary / pathology,  therapy*
Parenteral Nutrition / adverse effects,  methods*
Treatment Failure
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Fatty Acids, Omega-3
Comment In:
J Pediatr. 2010 Sep;157(3):517; author reply 518   [PMID:  20584532 ]
J Pediatr. 2011 Jul;159(1):170-1   [PMID:  21669322 ]

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