| Failure of multiple therapies in the treatment of a type 1 diabetic patient with insulin allergy: a case report. | |
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MedLine Citation:
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PMID: 20713334 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To describe the clinical manifestations of insulin allergy and explain a systematic management approach.Methods: We present the clinical, laboratory, and pathologic findings of a type 1 diabetic patient with allergy to subcutaneous insulin and briefly review the related literature.Results: An 18-year old woman with type 1 diabetes mellitus had an insulin allergy and developed subcutaneous nodules after insulin administration. Human and analogue insulins were used, but painful nodule formation persisted. Treatment with antihistamines, steroids, and omalizumab and insulin desensitization were ineffective. The patient required pancreatic transplant because glycemic control could not be achieved due to the insulin allergy.Conclusions: Insulin allergy is not a common condition and can be challenging in patients with type 1 diabetes. Therefore, identifying patients with true insulin allergy and applying a stepwise approach to their treatment is important. |
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Authors:
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Thomas Koroscil; Yasmin Kagzi; Dawn Zacharias |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 17 ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
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Languages: eng Pagination: 91-4 Citation Subset: IM |
Affiliation:
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Wright State University Boonshoft School of Medicine, Dayton, Ohio. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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