Document Detail

Failure of multiple therapies in the treatment of a type 1 diabetic patient with insulin allergy: a case report.
MedLine Citation:
PMID:  20713334     Owner:  NLM     Status:  In-Data-Review    
Objective: To describe the clinical manifestations of insulin allergy and explain a systematic management approach.Methods: We present the clinical, laboratory, and pathologic findings of a type 1 diabetic patient with allergy to subcutaneous insulin and briefly review the related literature.Results: An 18-year old woman with type 1 diabetes mellitus had an insulin allergy and developed subcutaneous nodules after insulin administration. Human and analogue insulins were used, but painful nodule formation persisted. Treatment with antihistamines, steroids, and omalizumab and insulin desensitization were ineffective. The patient required pancreatic transplant because glycemic control could not be achieved due to the insulin allergy.Conclusions: Insulin allergy is not a common condition and can be challenging in patients with type 1 diabetes. Therefore, identifying patients with true insulin allergy and applying a stepwise approach to their treatment is important.
Thomas Koroscil; Yasmin Kagzi; Dawn Zacharias
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  17     ISSN:  1934-2403     ISO Abbreviation:  Endocr Pract     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-02-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-4     Citation Subset:  IM    
Wright State University Boonshoft School of Medicine, Dayton, Ohio.
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