Document Detail

Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs.
MedLine Citation:
PMID:  12163283     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: It is controversial whether the use of prostaglandin inhibitors could prevent progressive dermal ischemia in the postburn stasis zone. This study evaluated the effect of Ibuprofen on preventing postburn dermal ischemia using an animal model of India ink perfusion and skin transparent preparation techniques. METHODS: The closely clipped backs of the guinea pigs were bathed in 75 degrees C water for 10s. Ibuprofen-treated groups were fed intragastrically with Ibuprofen (12.5mg/kg) every 6h. All animals were perfused with 70% India ink via a cervical artery cannula at 16 kPa constant pressure at 0, 8, 16, 24h postburn. Skin transparent preparations were made, and 6-keto-PGF(1 alpha) and T x B(2) levels in skin tissue were assessed. RESULTS: India ink filling rates in skin capillary plexuses decreased gradually with postburn time elapsing (P<0.01). 6-keto-PGF(1 alpha) and T x B(2) levels in two groups increased. The increase of T x B(2) was dominant, which was related to postburn dermal ischemia (r=0.742, P<0.01). Though levels of 6-keto-PGF(1 alpha) and T x B(2) decreased in Ibuprofen-treated groups, India ink filling rates showed no significant difference between controls and experimental groups (P>0.05). The results were also confirmed by observation of skin transparent preparations. CONCLUSION: This study suggests that Ibuprofen has no preventive effect on progressive dermal ischemia after burning.
Qian Tan; Zihao Lin; Wenxi Ma; Huairen Chen; Lei Wang; Guansen Ning; Xu Zhou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  28     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-06     Completed Date:  2002-11-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  England    
Other Details:
Languages:  eng     Pagination:  443-8     Citation Subset:  IM    
Department of Burns and Plastic Surgery, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, PR China.
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MeSH Terms
Burns / complications*,  pathology
Cyclooxygenase Inhibitors / therapeutic use*
Dermis / blood supply*,  drug effects,  pathology*
Disease Models, Animal
Guinea Pigs
Ibuprofen / therapeutic use*
Ischemia / etiology*,  pathology,  prevention & control*
Microcirculation / drug effects
Time Factors
Trauma Severity Indices
Treatment Failure
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 15687-27-1/Ibuprofen

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