| Failure of glycine-arginine-α-ketoisocaproic acid to improve high-intensity exercise performance in trained cyclists. | |
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MedLine Citation:
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PMID: 21411833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oral supplementation with glycine-arginine-α-ketoisocaproic acid (GAKIC) has previously been shown to improve exhaustive high-intensity exercise performance. There are no controlled studies involving GAKIC supplementation in well-trained subjects. The aim of the current study was to examine the effects of GAKIC supplementation on fatigue during high-intensity, repeated cycle sprints in trained cyclists. After at least 2 familiarization trials, 10 well-trained male cyclists completed 2 supramaximal sprint tests each involving 10 sprints of 10 s separated by 50-s rest intervals on an electrically braked cycle ergometer. Subjects ingested 11.2 g of GAKIC or placebo (Pl) during a period of 45 min before the 2 experimental trials, administered in a randomized and double-blind fashion. Peak power declined from the 1st sprint (M ± SD; Pl 1,332 ± 307 W, GAKIC 1,367 ± 342 W) to the 10th sprint (Pl 1,091 ± 229 W, GAKIC 1,061 ± 272 W) and did not differ between conditions (p = .88). Mean power declined from the 1st sprint (Pl 892 ± 151 W, GAKIC 892 ± 153 W) to the 10th sprint (Pl 766 ± 120 W, GAKIC 752 ± 138 W) and did not differ between conditions (p = .96). The fatigue index remained at ~38% throughout the series of sprints and did not differ between conditions (p = .99). Heart rate and ratings of perceived exertion increased from the 1st sprint to the 10th sprint and did not differ between conditions (p = .11 and p = .83, respectively). In contrast to previous studies in untrained individuals, these results suggest that GAKIC has no ergogenic effect on repeated bouts of high-intensity exercise in trained individuals. |
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Authors:
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Lukas Beis; Yaser Mohammad; Chris Easton; Yannis P Pitsiladis |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of sport nutrition and exercise metabolism Volume: 21 ISSN: 1526-484X ISO Abbreviation: Int J Sport Nutr Exerc Metab Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-17 Completed Date: 2011-03-29 Revised Date: 2012-03-02 |
Medline Journal Info:
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Nlm Unique ID: 100939812 Medline TA: Int J Sport Nutr Exerc Metab Country: United States |
Other Details:
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Languages: eng Pagination: 33-9 Citation Subset: IM |
Affiliation:
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College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Athletic Performance / physiology* Bicycling / physiology* Dietary Supplements* Double-Blind Method Hexanoic Acids / administration & dosage, pharmacology* Humans Male Muscle Fatigue / drug effects Physical Exertion / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Hexanoic Acids; 0/glycine-L-arginine-alpha-ketoisocaproic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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