| Failure of cerebral hemodynamic selection in general or of specific positron emission tomography methodology?: Carotid Occlusion Surgery Study (COSS). | |
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MedLine Citation:
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PMID: 21960571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The Carotid Occlusion Surgery Study (COSS) was an improvement over the Extracranial-Intracranial Bypass Study, which did not utilize physiological selection. To assess possible reasons for early closure of the COSS trial, we reviewed COSS methods used to identify high-risk patients and compared results with separate quantitative data. METHODS: Increased oxygen extraction fraction (OEF) by positron emission tomography is a gold standard for ischemia, but the specific thresholds and equivalency of the semiquantitative OEF ratio utilized in COSS and quantitative OEF are at issue. RESULTS: The semiquantitative hemispheric OEF ratio used in COSS did not identify the same group of patients as did quantitative OEF using a threshold of 50%. CONCLUSIONS: The failure of COSS is likely caused by a failure of the semiquantitative, hemispheric OEF ratio method rather than by the selection for bypass based on hemodynamic compromise. |
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Authors:
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Andrew P Carlson; Howard Yonas; Yue-Fang Chang; Edwin M Nemoto |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-09-29 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 42 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-29 Completed Date: 2012-08-13 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 3637-9 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University of New Mexico, MSC 10 5615, Albuquerque, NM 87131, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Ischemia
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etiology*,
physiopathology,
radionuclide imaging Carotid Stenosis / complications, physiopathology, radionuclide imaging, therapy* Humans Positron-Emission Tomography Randomized Controlled Trials as Topic Risk Factors Stroke / etiology*, physiopathology, radionuclide imaging |
| Grant Support | |
ID/Acronym/Agency:
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NS051639/NS/NINDS NIH HHS; NS061216/NS/NINDS NIH HHS; R01 NS051639-01/NS/NINDS NIH HHS; R01 NS051639-02/NS/NINDS NIH HHS; R01 NS051639-03/NS/NINDS NIH HHS; R01 NS051639-04/NS/NINDS NIH HHS; R01 NS051639-05/NS/NINDS NIH HHS |
| Comments/Corrections | |
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