Document Detail


Failure of an ACE inhibitor to improve exercise tolerance. A randomized study of trandolapril. Trandolapril study group.
MedLine Citation:
PMID:  9886725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There has been conflicting evidence of the effect of angiotensin-converting enzyme (ACE) inhibitors on exercise tolerance. Meta-analysis of published results has suggested that a beneficial effect of ACE inhibitors is demonstrated if a trial design is adequate. SETTING: Multicentre International Trial. METHODS: In a double-blind, randomized, multicentre trial, 292 patients with moderate (New York Heart Association Grades II and III) heart failure were treated with trandolapril or placebo in addition to diuretics, and followed for 16 weeks. Exercise tolerance on a treadmill was assessed at baseline and after 4, 8, 12 and 16 weeks of treatment. Both a modified Bruce and a modified Naughton protocol were used. RESULTS: Exercise tolerance improved in both treatment groups, with no significant benefit from trandolapril treatment. CONCLUSION: Trandolapril does not improve exercise tolerance as measured by treadmill testing.
Authors:
J R Hampton; A J Cowley; A M Wnuk-Wojnar
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  European heart journal     Volume:  19     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-24     Completed Date:  1999-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1823-8     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Medicine, University Hospital, Queen's Medical Centre, Nottingham, UK.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Double-Blind Method
Exercise Test
Exercise Tolerance / drug effects*
Female
Follow-Up Studies
Heart Failure / drug therapy*,  physiopathology
Humans
Indoles / therapeutic use*
Male
Middle Aged
Time Factors
Treatment Failure
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Indoles; 87679-37-6/trandolapril
Comments/Corrections
Comment In:
Eur Heart J. 1998 Dec;19(12):1747-9   [PMID:  9886714 ]
Eur Heart J. 1999 Nov;20(21):1600-1   [PMID:  10529329 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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