| Failure of 17-hydroxyprogesterone to reduce neonatal morbidity or prolong triplet pregnancy: a double-blind, randomized clinical trial. | |
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MedLine Citation:
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PMID: 20816146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test whether 17 alpha-hydroxyprogesterone caproate (17P) will reduce neonatal morbidity by increasing gestational age at delivery in triplet pregnancies. STUDY DESIGN: Double-blind, randomized clinical trial. Mothers carrying trichorionic-triamniotic triplets were randomly assigned (in a 2:1 ratio) to weekly injections of 250 mg of 17P or placebo, starting at 16-22 weeks and continued until 34 weeks. Primary outcome was composite neonatal morbidity. RESULTS: Fifty-six women were randomized to 17P and 25 to placebo. Composite neonatal morbidity occurred with similar frequency in the 17P and placebo groups (38% vs 41%, respectively; P = .71). Mean gestational age at delivery was not affected by 17P (31.9 vs 31.8 weeks; P = .36). There were 13 midtrimester fetal losses with 17P vs none with placebo (P < .02). CONCLUSION: In triplet pregnancy, prophylactic treatment with 17P did not reduce neonatal morbidity or prolong gestation but was associated with increased midtrimester fetal loss. |
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Authors:
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C Andrew Combs; Thomas Garite; Kimberly Maurel; Anita Das; Manuel Porto; |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-09-30 Revised Date: 2011-09-09 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 248.e1-9 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Obstetrix Medical Group, Sunrise, FL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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17-alpha-Hydroxyprogesterone
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therapeutic use* Abortion, Spontaneous / epidemiology Adult Double-Blind Method Female Fetal Death / epidemiology Gestational Age Humans Infant, Newborn Infant, Newborn, Diseases / epidemiology Pregnancy Pregnancy Complications / epidemiology Pregnancy, High-Risk* Pregnancy, Multiple* Premature Birth / prevention & control* Triplets* |
| Chemical | |
Reg. No./Substance:
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68-96-2/17-alpha-Hydroxyprogesterone |
| Investigator | |
Investigator/Affiliation:
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Thomas Garite / ; C Andrew Combs / ; Kimberly Maurel / ; Diana Abril / ; Anita F Das / ; James Thorp / ; Michael Gravett / ; Paul Meis / ; John Elliott / ; Melissa Ingersoll / ; Ana Braescu / ; Cecilia Lyons / ; Michael Nageotte / ; Christine Preslicka / ; James Kurtzman / ; Ann McCann / ; David Luthy / ; Tina Lopez / ; Dawn Artis / ; Shawn Stallings / ; Lorrie Mason / ; Hugh Miller / ; Diane Mercer / ; Manuel Porto / ; Pamela Rumney / ; Richard Porreco / ; Leslie Harden / ; Maryanne Bruno / ; Greg Lindsay / ; Gwen DuBois / ; Kent Heybourne / ; Marilyn Hall / ; William Stettler / ; Diane Lucero / ; George Lu / ; Mary Jean Brown / ; Neil Mandsager / ; Amie Dawes / ; Denise Cope / ; Andrew Combs / ; Kimberly Mallory / ; Jon Rosnes / ; Kristine Jones / ; Bannie Tabor / ; Alaine McAfee / ; Mary Root / ; Harris Methodist / ; Martin Walker / ; SallyAnn deVitry Smith / ; Donald Roberts / |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 2011 May;204(5):e16-7; author reply e17
[PMID:
21276949
]
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Erratum In:
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Am J Obstet Gynecol. 2011 Feb;204(2):166 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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