| Failed fertilization after clinical intracytoplasmic sperm injection. | |
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MedLine Citation:
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PMID: 20158989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracytoplasmic sperm injection (ICSI) has resulted in pregnancy and birth for many couples, including those with severe male factor infertility. However, even after ICSI, complete failure of fertilization occurs in 1-3% of cycles. Most cases occur due to low number of mature oocytes, failure of oocyte activation or non-availability of appropriate spermatozoa for injection. Given the significant emotional and financial involvement in assisted reproductive cycles, failure of fertilization in all mature oocytes is a distressful event. It is not predictable. Since follow-up ICSI cycles result in fertilization in 85% of cases, repeated ICSI attempts are suggested. Physicians should counsel patients experiencing repeated failure of fertilization after ICSI cycles about available options including donated oocytes/embryos, donor sperm insemination, adoption or remaining childless if these choices are not acceptable due to religious or ethical reasons. This review discusses the causes and remedies for failed fertilization after clinical ICSI. |
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Authors:
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Murid Javed; Navid Esfandiari; Robert F Casper |
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Publication Detail:
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Type: Journal Article; Retracted Publication; Review Date: 2009-10-30 |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 20 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-07-29 Revised Date: 2012-01-18 |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 56-67 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Toronto Centre for Advanced Reproductive Technology (TCART), 210-150 Bloor Street (W), Toronto, Ont., Canada M5S 2X9. murid.javed@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Fertilization in Vitro / adverse effects* Humans Infertility, Male / therapy* Male Oocyte Donation Oocytes / physiology Sperm Injections, Intracytoplasmic / adverse effects* Tissue Donors Treatment Failure |
| Comments/Corrections | |
Retraction In:
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Reprod Biomed Online. 2011 Dec;23(6):806
[PMID:
22250297
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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