Document Detail

Failed air supply to individually ventilated caging system causes acute hypoxia and mortality of rats.
MedLine Citation:
PMID:  19760835     Owner:  NLM     Status:  MEDLINE    
Greater than 30% mortality was observed unexpectedly in rat pups of weaning age kept with their dams in individually ventilated cages (IVC). A subsequent controlled study involving an induced electrical power failure that halted ventilation of IVC containing rat dams and pups showed that oxygen concentrations in the air in individual cages were rapidly depleted to less than 10% in 1 h. In a separate incident during which electrical power to IVC was inadvertently disconnected, rats died within 60 min of loss of power to IVC. The loss of electrical power to IVC housing rats is potentially a life-threatening condition requiring an immediate response and affirms the consideration of emergency (back-up) electrical power where these systems are used.
Michael J Huerkamp; Wesley D Thompson; Noel D M Lehner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science     Volume:  42     ISSN:  1060-0558     ISO Abbreviation:  Contemp Top Lab Anim Sci     Publication Date:  2003 May 
Date Detail:
Created Date:  2009-09-17     Completed Date:  2009-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204153     Medline TA:  Contemp Top Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-5     Citation Subset:  IM    
Division of Animal Resources, Emory University, Atlanta, Georgia 30322, USA.
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MeSH Terms
Animals, Laboratory
Animals, Suckling
Anoxia / mortality*
Environment, Controlled
Housing, Animal*
Rats, Long-Evans
Ventilation / methods*

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