Document Detail


Faecal pH, bile acid and sterol concentrations in premenopausal Indian and white vegetarians compared with white omnivores.
MedLine Citation:
PMID:  9771336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Faecal bulk, pH, water content, the concentrations of neutral sterols and bile acids and dietary intakes were measured in twenty-two Indian vegetarian, twenty-two white omnivorous and eighteen white vegetarian premenopausal women. Faecal bulk and water content were greater and pH lower in the Indian vegetarians. Total faecal animal sterol and coprostanol concentrations expressed on a dry-weight basis were lower in the vegetarians compared with the omnivores. The faecal sterol concentrations were correlated with dietary cholesterol intake. Primary bile acids were detected in six Indian vegetarians, two white vegetarians and two white omnivores; secondary bile acids were detected in all the white omnivores and vegetarian subjects but not in two of the Indian vegetarians. Total faecal free bile acid and conjugated bile acid concentrations were lower in the white vegetarians compared with the omnivores. Faecal lithocholic acid concentrations were lower in both Indian and white vegetarians. The lithocholic: deoxycholic acid ratio and coprostanol: total animal sterols ratio were significantly lower in the Indian vegetarians compared with the omnivores. Both ratios were positively correlated with faecal pH. Stepwise multiple regression analyses were undertaken in order to identify which nutrients influenced faecal pH, lithocholic and deoxycholic acid concentrations. The intakes of starch and dietary fibre were negatively associated with faecal concentrations of lithocholic and deoxycholic acid. Starch intake alone was negatively associated with faecal pH. The results of this study confirm that diets high in dietary fibre decrease faecal bile acid concentrations and suggest that the complex carbohydrates present in Indian vegetarian diets influence faecal pH and inhibit the degradation of faecal steroids.
Authors:
S Reddy; T A Sanders; R W Owen; M H Thompson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  79     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-19     Completed Date:  1998-10-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  495-500     Citation Subset:  IM    
Affiliation:
Nutrition Food & Health Research Centre, King's College London, UK. sreddy@doh.gov.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Bile Acids and Salts / analysis*
Cholestanol / analysis
Deoxycholic Acid / analysis
Diet, Vegetarian*
Dietary Fiber / administration & dosage
England
Feces / chemistry*
Female
Humans
Hydrogen-Ion Concentration
India / ethnology
Lithocholic Acid / analysis
Regression Analysis
Sterols / analysis*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Sterols; 434-13-9/Lithocholic Acid; 80-97-7/Cholestanol; 83-44-3/Deoxycholic Acid

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