| Faecal elastase 1 levels in premature and full term infants. | |
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MedLine Citation:
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PMID: 12598497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Determination of faecal elastase 1 (FE1) is a simple, relatively inexpensive, non-invasive, highly specific and sensitive test for determining pancreatic function. Secretion of pancreatic enzymes varies during infancy, but there are almost no specific data on the ontogeny of elastase 1 in human babies. AIM: To study FE1 levels in preterm and term babies, and to determine the possible effect of gestational and postconceptual age on these levels. METHODS: Serial stool samples were collected and tested for FE1 level from 77 premature and full term infants. FE1 levels were determined by a commercially available enzyme linked immunosorbent assay (ELISA) kit. RESULTS: A total of 232 stool samples were collected from 77 neonates. The FE1 level measured in the first stool sample (meconium) was below normal (200 micro g/g stool) in all samples regardless of gestational age. Sixty three neonates had at least two samples tested for FE1 level. The mean (SD) level of FE1 in sample 1 was 45.9 (51.1) micro g/g stool and was significantly (p < 0.001) lower than in sample 2 (243.0 (164.9) micro g/g stool). The lower the gestational age of the newborn, the more time it took for FE1 to reach normal levels. CONCLUSIONS: FE1 levels in meconium are low, and studies in meconium should be avoided if pancreatic sufficiency is to be determined. FE1 reaches normal levels by day 3 in term newborns and by 2 weeks in infants born before 28 weeks gestation. Normal levels are reached sooner in infants of more advanced gestational age who start enteral feeding earlier. |
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Authors:
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M Kori; A Maayan-Metzger; R Shamir; L Sirota; G Dinari |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 88 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-02-24 Completed Date: 2003-04-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: England |
Other Details:
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Languages: eng Pagination: F106-8 Citation Subset: AIM; IM |
Affiliation:
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Institute of Pediatric Gastroenterology and Nutrition, Schneider Children's Medical Center of Israel, Petah Tikva, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism Biological Markers / analysis Enzyme-Linked Immunosorbent Assay Feces / enzymology* Female Gestational Age Humans Infant, Newborn Infant, Premature / metabolism* Male Meconium / enzymology Pancreatic Elastase / analysis* Pancreatic Function Tests / methods Reference Values Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; EC 3.4.21.36/Pancreatic Elastase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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