Document Detail


Faecal calprotectin levels in infants with infantile colic, healthy infants, children with inflammatory bowel disease, children with recurrent abdominal pain and healthy children.
MedLine Citation:
PMID:  11883817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated faecal calprotectin concentration, a measure of intestinal inflammation, in infants and children with abdominal pain. Faecal calprotectin was measured by an enzyme-linked immunosorbent assay kit in spot stool samples in 76 infants with typical infantile colic, 7 infants with transient lactose intolerance and 27 healthy infants. All infants were 2-10 wk of age. In addition, 19 children with recurrent abdominal pain (RAP; mean age 11.5 y), 17 with inflammatory bowel disease (IBD; mean age 11.1 y; 10 had Crohn's disease and 7 ulcerative colitis) and 24 healthy children (mean age 5.3 y) were studied. In infants with infantile colic the mean faecal calprotectin concentration was not different from that in healthy infants (278 +/- 105 vs 277 +/- 109 mg kg(-1), p = 0.97) or in infants with transient lactose intolerance (300.3 +/- 124 mg kg(-1), p = 0.60). The calprotectin level was similar in boys and girls and fell significantly with age (p = 0.04). Children with IBD had faecal calprotectin levels (293 +/- 218 mg kg(-1)) much higher than healthy children (40 +/- 28 mg kg(-1), p < 0.0001) and children with RAP without identified organic disease (18 +/- 24 mg kg(-1), p < 0.0001). Conclusion: Faecal calprotectin may differentiate between functional abdominal pain and IBD in school-aged children. In young infants high faecal calprotectin levels are normal.
Authors:
E Olafsdottir; L Aksnes; G Fluge; A Berstad
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  91     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2002  
Date Detail:
Created Date:  2002-03-08     Completed Date:  2002-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  45-50     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, University of Bergen, Norway. eola@haukeland.no
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MeSH Terms
Descriptor/Qualifier:
Abdominal Pain / diagnosis*
Adolescent
Age Factors
Biological Markers / analysis
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Diagnosis, Differential
Diarrhea, Infantile / diagnosis*
Feces / chemistry*
Female
Humans
Infant
Infant, Newborn
Inflammatory Bowel Diseases / diagnosis*
Leukocyte L1 Antigen Complex
Male
Membrane Glycoproteins / analysis,  metabolism*
Neural Cell Adhesion Molecules / analysis,  metabolism*
Probability
Recurrence
Sensitivity and Specificity
Sex Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Leukocyte L1 Antigen Complex; 0/Membrane Glycoproteins; 0/Neural Cell Adhesion Molecules

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