| Faecal calprotectin in colonic diverticular disease: a case-control study. | |
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MedLine Citation:
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PMID: 18941760 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Information about faecal calprotectin (FC) in colonic diverticular disease (DD) are lacking. We assessed FC in colonic DD, comparing it with irritable bowel syndrome (IBS) patients and healthy controls. Moreover, we compared FC levels in different degrees of DD and assessed FC in symptomatic DD before and after treatment. MATERIALS AND METHODS: Forty-eight consecutive patients with a new endoscopic diagnosis of DD (16 with asymptomatic diverticulosis, 16 with symptomatic uncomplicated DD, 16 with acute uncomplicated diverticulitis), 16 healthy controls, and 16 IBS patients were studied. FC was assessed by semi-quantitative method and compared with histological inflammation. Moreover, FC was reassessed in symptomatic DD after 8 weeks of treatment. RESULTS/FINDINGS: FC was not increased in healthy controls and IBS patients. No difference was found between asymptomatic diverticulosis, healthy controls, and IBS patients (p = n.s.). We found higher FC values in acute uncomplicated diverticulitis (p < 0.0005) and in symptomatic uncomplicated DD (p < 0.005) than in healthy controls and in IBS patients. FC values correlated with inflammatory infiltrate (p < 0.0005). FC decreased after treatment to normal values both in acute uncomplicated diverticulitis (p < 0.0005) and in symptomatic uncomplicated DD (p < 0.005) after treatment. INTERPRETATIONS/CONCLUSIONS: FC may be useful to detect colonic inflammation in DD and in distinguishing symptomatic DD from IBS, as well as in assessing response to therapy in DD. |
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Authors:
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Antonio Tursi; Giovanni Brandimarte; Walter Elisei; Gian Marco Giorgetti; Cosimo Damiano Inchingolo; Fabio Aiello |
Publication Detail:
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Type: Journal Article Date: 2008-10-22 |
Journal Detail:
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Title: International journal of colorectal disease Volume: 24 ISSN: 0179-1958 ISO Abbreviation: Int J Colorectal Dis Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-11-26 Completed Date: 2009-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607899 Medline TA: Int J Colorectal Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 49-55 Citation Subset: IM |
Affiliation:
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Digestive Endoscopy Unit, "Lorenzo Bonomo" Hospital, Via Torino, 49, 70031, Andria, BA, Italy. antotursi@tiscali.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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therapeutic use Case-Control Studies Colonoscopy Diverticulosis, Colonic / drug therapy, metabolism* Feces / chemistry* Female Gastrointestinal Agents / therapeutic use Humans Irritable Bowel Syndrome / metabolism Leukocyte L1 Antigen Complex / metabolism* Lymphocytes / metabolism Male Mesalamine / therapeutic use Middle Aged Neutrophils / metabolism Rifamycins / therapeutic use Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Gastrointestinal Agents; 0/Leukocyte L1 Antigen Complex; 0/Rifamycins; 88747-56-2/rifaximin; 89-57-6/Mesalamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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