Document Detail

Fading renal hyperfiltration in children following liver transplantation.
MedLine Citation:
PMID:  11260489     Owner:  NLM     Status:  MEDLINE    
In a prospective longitudinal study, we investigated the renal function (RF) of 23 children before and after orthotopic liver transplantation (OLT). The aim was to assess both the outcome of pretransplant hyperfiltration and the clinical nephrotoxic effects of cyclosporin A (CsA); children with decreased RF prior to OLT were therefore excluded. The RF study of the 13 remaining patients included glomerular filtration rate (GFR) and effective renal plasma flow (RPF) measured by inulin (Cin: mL/min/1.73 m2) and para-amino hippurate (Cpah: mL/min/1.73 m2) clearances, respectively. Hyperfiltration prior to OLT was observed in six children, i.e. Cin>170 [range 172-230] and Cpah>800 [808-1,133]. A significant decrease in RF was noted as soon as 6 months after OLT: Cin (mean+/-SD)=107+/-23 vs. 158+/-46 (p<0.003); Cpah=583+/-119 vs. 791+/-243 (p<0.004). This was due to loss of hyperfiltration in the six children, as there was no significant difference in RF before and 6 months after OLT in the other seven children. With a 36-month follow-up, there was no correlation between CsA trough blood level and RF. In conclusion, following OLT, RF underwent early changes owing to loss of prior hyperfiltration in children without impaired RF before OLT. In addition, no evidence of CsA nephrotoxicity was found and RF remained stable during follow-up.
M Schell; A Lachaux; A Hadj-Aïssa; L Dubourg; A Mahmoud; O Boillot; M H Saïd; P Cochat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric transplantation     Volume:  5     ISSN:  1397-3142     ISO Abbreviation:  Pediatr Transplant     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-30     Completed Date:  2001-05-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9802574     Medline TA:  Pediatr Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  51-5     Citation Subset:  IM    
Département de Pédiatrie, H pital Edouard Herriot, Lyon, France.
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MeSH Terms
Child, Preschool
Cyclosporine / administration & dosage,  adverse effects*
Glomerular Filtration Rate / physiology*
Graft Rejection / immunology,  prevention & control
Immunosuppressive Agents / administration & dosage,  adverse effects*
Kidney / drug effects,  physiology
Kidney Failure, Acute / etiology
Liver Transplantation / physiology*
Longitudinal Studies
Prospective Studies
Renal Plasma Flow / physiology*
Reg. No./Substance:
0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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