Document Detail


Factors which influence alterations of phosphates and pH in exercising human skeletal muscle: measurement error, reproducibility, and effects of fasting, carbohydrate loading, and metabolic acidosis.
MedLine Citation:
PMID:  7799999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have shown considerable variability in the metabolic response of human skeletal muscle during a standardized exercise protocol. The goal of these studies was to investigate the factors responsible for the broad range of metabolic changes produced by fatiguing exercise. Experiments were performed to quantitate the measurement error of 31P nuclear magnetic resonance spectroscopy of human muscle, the reproducibility of changes within a single subject, and the effects of fasting, carbohydrate loading, and metabolic acidosis. The results show that none of these factors appear to be responsible for the wide variation between subjects. However, the effects of training and genetic factors were not investigated and are likely to be responsible for the substantial variability between subjects.
Authors:
R G Miller; P J Carson; R S Moussavi; A Green; A Baker; M D Boska; M W Weiner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Muscle & nerve     Volume:  18     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-01-23     Completed Date:  1995-01-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  60-7     Citation Subset:  IM; S    
Affiliation:
Department of Neurology, California Pacific Medical Center, San Francisco 94118.
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MeSH Terms
Descriptor/Qualifier:
Acidosis / metabolism
Adult
Dietary Carbohydrates / pharmacology
Fasting
Female
Humans
Hydrogen / metabolism*
Hydrogen-Ion Concentration
Isometric Contraction
Male
Middle Aged
Muscle, Skeletal / metabolism*,  physiology
Phosphates / metabolism*
Physical Exertion*
Reproducibility of Results
Grant Support
ID/Acronym/Agency:
R01 DK 33293-05/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Phosphates; 1333-74-0/Hydrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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